脂联素和抵抗素与妊娠期糖尿病的相关性研究

目的 探讨脂联素、抵抗素与妊娠期糖尿病的关系及其在妊娠期糖尿病发病中的作用；妊娠期糖尿病脂联素与抵抗素的相关性.方法选取产科门诊孕28～32周的孕妇,进行糖筛查(GCT)试验,异常者再行OGTT试验.按结果进行分组:正常糖代谢组(NGT)30例、糖耐量异常组(GIGT )21例、妊娠期糖尿病组(GDM )32例.利用E...

Study on the Correlation of Serum Adiponectin and Resistin with Gestational Diabetes Mellitus Pregnant Women

Objective To investigate serum concentration of adiponectin and resistin and their correlation with insulin resistance in preg-
nant women with gestational diabetes mellitus（GDM）；To investigate the correlation between adiponectin and resistin of GDM. Methods 50-
g glucose screening test was conducted for many cases pregnant women at 28～32 weeks of pregnancy. If the blood sugar value was abnormal
to examine with oral glucose tolerance test（OGTT）. According to the result of OGTT，three groups were divided. The first group was 30 cas-
es of normal glucose tolerance（NGT），the second group was 21 cases of impaired glucose tolerance（GIGT），the third group was 32 cases of
gestational diabetes mellitus （GDM）. ELISA technique was employed to determine the serum adiponectin and resistin concentration，at the
same time the fasting blood glucose，insulin concentration were detected. Insulin resistance index was calculated by HOMA，and the depend-
ability of index was analyzed. Results （1）In the NGT，GIGT and GDM groups the serum adiponectin level tended to decrease gradually in
turn（ P< 0.01），but the level of serum resistin tended to advance gradually in turn （ P< 0.01），especially in the GDM. （2）Serum
adiponectin correlated negatively with insulin resistance index，fasting blood glucose and BMI（ P< 0.01），whereas resistin correlated positively
with the index above（ P< 0.01），serum adiponectin correlated negatively with resistin of GDM（ P< 0.01）. Conclusion Adiponectin is one
of the protection factors of GDM；resistin promotes the development of GDM by enhance insulin resistance index. It could be used as a new
sensitive indicator to evaluate the degree of insulin resistance in GDM and it can be a new target of treatment of GDM.