脑白质病变相关性轻度认知功能障碍患者神经心理学特征分析

目的观察脑白质病变(WML)对轻度认知功能损害(mild cognitive impairment,MCI)患者神经心理学的影响。方法 WML-MCI患者和健康对照者进行常规核磁共振及神经心理学检查,观察WML对MCI患者神经心理学的影响,并对其机制进行探讨。结果 WML-MCI组与对照组相比,高血压、糖尿病和冠心病比例明显增高;词语流畅性测验、积木测验和画钟测验评分均明显降低(P<0.05);而2组间MMSE、数字广度测验和词语延迟回忆测验评分无明显差异。结论 WML影响MCI患者的认知功能,主要表现为视空间及执行功能。血管危险因素是MCI发病的危险因素。

Charactistics of cognitive impairment in the patients with both mild cognitive impairment and white matter lesions

Objective To investigate the effect of white matter lesions(WML) on neuropsychological assessment in mild cognitive impairment(MCI).Methods Fifty-one elderly persons with WMI-MCI and 60 elderly normal people underwent conventional MRI and neuropsychological assessment.The correlations between white matter lesions and cognitive functions were analyzed.Results The subjects with WML-MCI had higher prevalence of hypertension and diabetes and coronary artery disease than control subjects.All the scores of verbal fluency,block test and clock-drawing test in WML-MCI group were lower than those in control group(P<0.05).The scores of MMSE,the digit span test and delayed memory test were not significantly different between WMI-MCI and control subjects.Conclusion WML influences cognitive functions in MCI.Vascular risk factors are risk factors for presence of MCI.