白细胞介素-6、12在乙型病毒性肝炎发病中的临床意义

目的探讨白细胞介素-6(interleukin-6,IL-6)、白细胞介素-12(interleukin-12,IL-12)在乙型病毒性肝炎发病机理中的临床意义。方法选择乙型病毒性肝炎患者138例,其中48例为急性乙型病毒性肝炎患者,男34例、女14例,年龄19￣58岁;52例为慢性乙型病毒性肝炎患者,男41例、女11例,年龄23￣69岁;38例为重型乙型病毒性肝炎患者,男31例、女7例,年龄21￣70岁。正常对照组60例,均为健康献血员。采用酶联免疫吸附试验(enzyme-linkedimmunosorbentassay,ELISA)双抗体夹心法检测各组乙型肝炎患者及正常对照组血清中IL-6、IL-12水平。结果三组IL-6、IL-12水平与正常对照组比较均有显著性差异(P<0.05);重型乙型肝炎组与急性及慢性乙型肝炎组比较,IL-6有显著性差异(P<0.01);急性乙型肝炎组与慢性及重型乙型肝炎组比较,IL-12有显著性差异(P<0.01);其余各组之间的比较无统计学意义。结论IL-6的变化与乙型肝炎肝细胞损害程度密切相关,而IL-12则在机体的抗病毒免疫应答中起重要作用,其值升高可能预示肝病向良好转归。

The clinical significance of IL-6 and IL-12 in diagnosis and treatment of patients with hepatitis B

Objective To discuss the significance of interlukin-6(IL-6) and interlukin-12(IL-12) in the immunity pathogenesis of hepatitis B. Methods All of 138 patients with hepatitis B, total 48 with acute hepatitis B (34 males and 14 females, aging from 19 to 58 years old), and 52 caces with chronic hepatitis B (41 males and 11 females, aging from 23 to 69 years old), while 38 cases with heavy hepatitis B (31 males and 7 females, aging from 21 to 70 years old) were collected in this study. Using two-antibody ELISA to detect IL-6, IL-12 in the patients with hepatitis B and 60 health as the control group. Results The IL-6 and IL-12 of each group have significantly difference contrast with control group (P< 0.05). Heavy hepatitis B group contrast with actue and chronic hepatitis B groups, IL-6 has significantly difference(P< 0.01). And acute hepatitis B group contrast with chronic and heavy hepatitis B groups, IL-12 has significantly difference(P< 0.01). Conclusion The change of IL-6 level is highly corelative to liver cells damage in hepatitis B. And IL-12 may plays an important role in antivirus immuno-responsion, the increase of its value suggest that liver disease would make a good progress.