氨氯地平贝那普利片治疗原发性高血压的临床疗效和安全性

目的探讨氨氯地平贝那普利片治疗原发性高血压的临床疗效和安全性。方法100例原发性高血压患者根据治疗方法不同分为观察组和对照组，每组50例。对照组患者给予盐酸贝那普利片20mg，每日1次，治疗12周；观察组患者给予氨氯地平贝那普利片1片，每日1次，治疗12周；比较2组患者临床疗效和不良反应。结果观察组和对照组患者治疗总有效率分别为98．00％和84．00％，观察组总有效率显著高于对照组（P〈0．05）。治疗前2组患者收缩压（SBP）和舒张压（DBP）比较差异均无统计学意义（P〉0．05）；治疗后2组患者SBP和DBP显著低于治疗前（P〈0．05）；治疗后观察组患者SBP和DBP显著低于对照组（P〈0．05）。2组患者不良反应发生率比较差异无统计学意义（P〉0．05）。结论氨氯地平贝那普利片治疗原发性高血压安全、有效，且无严重不良反应。

Clinical effect and safety of amlodipine besylate and benazepril hydrochloride tablets in treatment of essential hypertension

Objective To explore the clinical effect and safety of amlodipine besylate and benazepril hydrochloride tab- lets in treatment of essential hypertension. Methods A total of 100 patients with essential hypertension were divided into ob- servation group and control group according to different treatments,50 cases in each group. The patients in control group were treated with 20 mg benazepril hydrochloride tablets, once a day for 12 weeks. The patients in observation group were treated with 1 tablet amlodipine besylate and benazepril hydrochloride tablets, once a day for 12 weeks. The clinical effect and adverse effect were compared between the two groups. Results The total effective rate in observation group and control group was 98.00% and 84. 00%, respectively; the total effective rate in observation group was significantly higher than that in control group（ P 〈 0. 05 ）. There was no significant difference in SBP and DBP before treatment between the two groups （P 〉 0.05 ）. The SBP and DBP after treatment were significantly lower than those before treatment（P 〈 0.05）. The SBP and DBP in obser- vation group were significantly lower than those in control group after treatment（ P 〈 0.05 ）. There was no significant difference in adverse effect incidence between the two groups （ P 〉 0.05 ）. Conclusion Amlodipine besylate and benazepril hydrochlo- ride tablets for treating patients with essential hypertension is safe and effective with few severe adverse effect.