妊娠中晚期产妇血清25羟维生素D3与妊娠结局的相关性分析

目的]探讨妊娠中晚期产妇血清25-羟维生素D325(OH)D3]与妊娠结局的相关性.方法]回顾性分析2014年2月至2015年1月在本院妇产科进行孕检的124例正常中晚期孕妇的临床资料,根据孕妇血清中25(OH)D3水平分为缺乏组25(OH)D3<25 nmol/L,n=42例]、不足组(25～75) nmol/L,n=52例]和充足组25(OH)D3>75 nmol/L,n=30例],比较三组妊娠产妇不良妊娠结局及并发症.结果]缺乏组孕妇中流产、早产及子痫前期发生率分别为35.71％、47.62％和30.92％,明显高于不足组(15.38％、26.92％和19.23％)和充足组(6.67％、16.67％和3.33％),差异具有统计学意义(P<0.05).缺乏组孕妇细菌性阴道病和贫血发生率为38.1％和28.57％,明显高于不足组(17.31％和25.0％)和充足组(13.33％和6.67％),差异具有统计学意义(P<0.05).缺乏组孕妇分娩周期为(37.12±0.52)周,显著短于不足组(38.24±1.02)周和充足组(39.57±1.45)周,差异具有统计学意义(P<0.05).结论]妊娠中晚期产妇血清25羟维生素D3含量缺乏或不足,可增加不良妊娠结局及妊娠合并症发生的风险,同时导致胎儿发育受限.

Study on the Relationship Between Serum 25-hydroxyvitamin D in Pregnant Women in the Second or Third-trimester of Pregnancy and Pregnancy Outcomes

Objective]To investigate the relationship between serum 25-hydroxyvitamin D3 in pregnant women in the second or third-trimester of pregnancy and pregnancy outcomes.Methods]The clinical data of 124 pregnant women in the second or third-trimester of pregnancy who received antenatal care in our hospital between February 2014 and January 2015 were analyzed retrospectively.According to the levels of serum 25 (OH)D3, the pregnant women were divided into the deficiency group 25 (OH) D3 level<25 nmol/L,n=42], insufficiency group (25 nmol/L< 25 (OH) D3 level < 50 nmol/L,n=52) and sufficiency group (25 (OH) D3 level >75 nmol/L,n=30).The adverse pregnancy outcomes and complications were compared between groups.Results]The incidence rates of abortion, preterm labor, preeclampsia, bacterial vaginosis and anemia in the deficiency group (35.71％, 47.62％, 30.92％, 38.1％, 28.57％) were significantly higher than those in the insufficiency group (15.38％, 26.92％, 19.23％, 6.67％, 17.31％) and the sufficiency group (6.67％,16.67％, 3.33％, 13.33％, 25.0％)(P<0.05).The delivery cycle of the deficiency group (37.12±0.52) weeks] was significantly shorter than that of the insufficiency group (38.24±1.02) weeks] and the sufficiency group (39.57±1.45) weeks](P<0.05).Conclusion]Deficiency or insufficiency of serum 25-hydroxyvitamin D3 in pregnant women in the second or third trimester of pregnancy can increase the risk of adverse pregnancy outcomes and the incidence of pregnancy complications, and it can lead to fetal growth retardation.