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| SCNN1A基因多态性与土家族、苗族及汉族人群原发性高血压相关性的研究 | |
| 引用本文： | 向波,王晓春,周明欢,张业军,钟飞,陈正英,周卫华,彭湘萍,符自清,李文悌.SCNN1A基因多态性与土家族、苗族及汉族人群原发性高血压相关性的研究[J].临床心血管病杂志,2011,27(10). |
| 作者姓名： | 向波 王晓春 周明欢 张业军 钟飞 陈正英 周卫华 彭湘萍 符自清 李文悌 |
| 作者单位： | 1. 中南大学湘雅医学院医学检验系,长沙,410013;吉首大学第一附属医院检验科 2. 中南大学湘雅医学院医学检验系,长沙,410013 3. 吉首大学第一附属医院三病室 4. 吉首大学医学院 5. 吉首大学第一附属医院检验科 |
| 基金项目： | 湖南省卫生厅科研基金资助项目(No:B2011-150); 吉首大学校级科研资助项目(No:11JD071) |
| 摘 要： | 目的:探讨上皮细胞钠通道α亚基(SCNN1A)基因单核苷酸多态性位点rs2228576与湘西土家族、苗族和汉族人群原发性高血压(EH)的相关性。方法:用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术分析土家族(120例)、苗族(117例)和汉族(125例)人群EH患者(EH组)与正常人群正常对照组(土家族119例、苗族125例、汉族122例)]SCNN1A等位基因频率分布状况。结果:土家族、苗族和汉族均存在3种AA、AG及GG基因型;土家族、苗族和汉族正常对照组基因型频率分别为(0.109,0.538,0.353;0.152,0.472,0.376;0.164,0.541,0.295);各族EH组与正常对照组基因型频率差异均无统计学意义(χ2=5.662,P>0.843);等位基因频率差异均无统计学意义(χ2=3.538,P>0.618)。结论:3个民族均存在SCNN1A基因rs2228576多态性位点,但该多态性位点与3个民族EH无明显相关性。 |
| 关 键 词： | 上皮细胞钠通道α亚基 原发性高血压 单核苷酸多态性 |
Correlation of the SCNN1A gene polymorphism and the essential hypertension in Tujia,Miao and Han Chinese |
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| XANG Bo,WANG Xiaochun,ZHOU Minghuan,ZHANG Yejun,ZHONG Fei,CHEN Zhengying,ZHOU Weihua,PENG Xiangping,FU Ziqing,LI Wenti.Correlation of the SCNN1A gene polymorphism and the essential hypertension in Tujia,Miao and Han Chinese[J].Journal of Clinical Cardiology,2011,27(10). | |
| Authors: | XANG Bo WANG Xiaochun ZHOU Minghuan ZHANG Yejun ZHONG Fei CHEN Zhengying ZHOU Weihua PENG Xiangping FU Ziqing LI Wenti |
| Affiliation: | XANG Bo1,2 WANG Xiaochun1 ZHOU Minghuan3 ZHANG Yejun4 ZHONG Fei4 CHEN Zhengying4 ZHOU Weihua4 PENG Xiangping4 FU Ziqing2 LI Wenti1(1Department of Laboratory Medicine,Xiangya Medical School,Central South University,Changsha,410013,China,2Department of Clinical Laboratory,The First Affiliated Hospital of Jishou University,3The Third Ward,4Department of Molecular Biology Laborotory,Medical College of Jishou University) |
| Abstract: | Objective:To investigate the association between the epithelial Na(+) channel subunit alpha(SCNN1A) gene's single nucleotide polymorphism(SNP),rs2228576 and essential hypertension(EH) of Tujia,Miao and Han Chinese in Xiangxi area.Method:The study recruited 120 Tujia,117 Miao and 125 Han Chinese patients with EH as the EH group and 119 Tujia,125 Miao and 122 Han healthy people as the control group(NT) respectively.The rs2228576 polymorphism of SCNN1A gene was analyzed by PCR-RFLP.Results:There were three kin... |
| Keywords: | epithelial sodium channel essential hypertension single-nucleotide polymorphism |
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