| 孕酮和孕烯醇酮硫酸盐对东莨菪碱引起的小鼠记忆损伤的保护作用 |
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| 引用本文： | 王丹,于榕,鲁映青,姚明辉.孕酮和孕烯醇酮硫酸盐对东莨菪碱引起的小鼠记忆损伤的保护作用[J].中国临床药理学与治疗学,2004,9(9):1030-1032. |
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| 作者姓名： | 王丹 于榕 鲁映青 姚明辉 |
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| 作者单位： | 复旦大学上海医学院药理学系,上海,200032 |
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| 基金项目： | ProjectsupportedbyNaturalScienceFoundationofShanghai (№ 0 2ZB14 0 0 7) |
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| 摘 要： | 目的 :观察孕酮和孕烯醇酮硫酸盐对东莨菪碱引起的小鼠记忆损伤的保护作用。方法 :用东莨菪碱造成小鼠记忆损伤的模型 ,应用被动避暗试验测定潜伏期以评价记忆成绩。结果 :小鼠给予东莨菪碱 (1mg·kg-1,ip)后 ,其潜伏期显著减少 ,表明造成了明显的记忆损伤。孕酮 (1,10mg·kg-1,sc)和孕烯醇酮硫酸盐 (1mg·kg-1,sc)均可以在被动避暗试验中减轻东莨菪碱引起的记忆损伤。结论 :孕酮和孕烯醇酮硫酸盐可改善记忆损伤。
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| 关 键 词： | 孕酮 孕烯醇酮硫酸盐 东莨菪碱 记忆 被动避暗试验 |
Protective effects of progesterone and pregnenolone sulfate on memory impairment mice induced by scopolamine |
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| Abstract.Protective effects of progesterone and pregnenolone sulfate on memory impairment mice induced by scopolamine[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2004,9(9):1030-1032. |
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| Authors: | Abstract |
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| Abstract: | AIM: To investigate the protective effects of progesterone and pregnenolone sulfate on memory impairment mice induced by scopolamine. METHODS:Pharmacological model of amnesia in mice was induced by scopolamine. Memory result was evaluated by the stepthrough latency in the passive-avoidance task. RESULTS: Animals displayed marked decrease in the stepthrough latency after administration (scopolamine 1cantly decreased performance of animals in the passiveavoidance task. CONCLUSION: Progesterone and pregnenolone sulfate can ameliorate the memory deficit. |
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| Keywords: | progesterone pregnenolone sulfate scopolamine memory passive-avoidance task |
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