| 柔红霉素隐形脂质体的药剂学性质 |
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| 引用本文： | 张华,齐宪荣,张强.柔红霉素隐形脂质体的药剂学性质[J].中国药学,2001,10(4):200-202. |
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| 作者姓名： | 张华 齐宪荣 张强 |
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| 作者单位： | 北京大学药学院药剂教研室 北京100083
(张华，齐宪荣)，北京大学药学院药剂教研室 北京100083(张强) |
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| 摘 要： | 本文研究了柔红霉素隐形脂质体的药剂学性质。考察了柔红霉素隐形脂质体的形态和粒径分布;考察了柔红霉素隐形脂质体的包封率和脂质体在Hepes缓冲液(pH 7.5)和大鼠血清中的体外释放行为。结果表明所制备的柔红霉素隐形脂质体包封率高(>85%),平均粒径为56.3 nm,体外释放慢。结论认为制备的隐形脂质体包封率较高,药剂学性质较好,适于临床使用。
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| 关 键 词： | 柔红霉素 脂质体 药剂学性质 包封率 体外释放 临床使用 血清 隐形 平均粒径 制备 |
Pharmaceutical Characteristics of Daunorubicin Stealth Liposomes |
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| Zhang Hua,Qi Xianrong and Zhang Qiang.Pharmaceutical Characteristics of Daunorubicin Stealth Liposomes[J].Journal of Chinese Pharmaceutical Sciences,2001,10(4):200-202. |
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| Authors: | Zhang Hua Qi Xianrong and Zhang Qiang |
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| Affiliation: | Zhang Hua,Qi Xianrong and Zhang Qiang* Department of Pharmaceutics,School of Pharmaceutical Sciences,Peking University,Beijing 100083 |
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| Abstract: | This report studied on pharmaceutical characteristics of the stealth liposome containing dau-norubicin (DNR). The shape, size, entrapment efficiency and stability of the daunorubicin stealth liposomes (DNRSL) were examined. Visible spectrophotometry and the HPLC method were established for determination of the DNR in the DNRSL. The release of DNR from DNRSL in HBS (pH 7.5) and rat serum at 37 oC were examined. The results showed that the DNRSL had high entrapment efficiency (>85%), small size and slow release. |
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| Keywords: | Stealth liposomes Daunorubicin Entrapment efficiency Drug release in vitro |
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