Studies on fine structure and location of lipids in quick-freeze replicas of atherosclerotic aorta of WHHL rabbits |
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Authors: | Kimiko Amanuma Toku Kanaseki Yohko Ikeuchi Shoji Ohkuma Tatsuya Takano |
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Affiliation: | (1) Department of Microbiology and Molecular Pathology, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, 199-01 Kanagawa;(2) Department of Genetics, Tokyo Metropolitan Institute for Neurosciences, Fuchu, 183 Tokyo, Japan;(3) Present address: Cell Sci. Tech. Div., Ferm. Res. Inst., 305 Tsukuba, Ibaraki, Japan |
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Abstract: | Summary The fine structure of intracellular and extracellular lipids in the atherosclerotic aorta of Watanabe-heritable hyperlipidemic (WHHL) rabbits was demonstrated by a quick-freeze etching technique. Many lipid droplets, with and without a membrane, were observed in the foam cells. Membrane-free droplets were observed as onionlike structure with a concentric lamellar structure surrounded by 10 nm filaments. Droplets surrounded by a limited membrane probably correspond to lipid-laden lysosomes.In the extracellular connective tissue space, marked accumulation of lipids with a vesicular structure was seen among collagen fibers. The appearance of these lipids was similar to that of lipids in lysosomes of foam cells. |
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Keywords: | Atherosclerosis Quick-freeze replica Lipid deposit Foam cell Extracellular lipid |
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