| 鼻咽癌病人EB病毒EBNA—2A及EBNA—LPIgG和IgA抗体的测定 |
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| 引用本文： | 韩汝晶 Huang,F.鼻咽癌病人EB病毒EBNA—2A及EBNA—LPIgG和IgA抗体的测定[J].病毒学报,1990,6(3):228-232. |
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| 作者姓名： | 韩汝晶 Huang F |
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| 作者单位： | 吉林医学院
(韩汝晶)，美国哈佛大学医学院微生物室
(F.Huang，E.Kieff)，中国预防医学科学院病毒学研究所(曾毅) |
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| 摘 要： |
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| 关 键 词： | 鼻咽肿瘤 EB病毒 核抗原 |
DETECTION OF IgG AND IgA ANTIBODIES TO EPSTEIN-BARR VIRUS EBNA-2A AND E8NA-LP IN SERA FROM PATIENTS WITH NA30PHA-RyNGEAL CARCINOMA AND FROM NORMAL INDIVIDUALS |
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| Han Rujing F. Huang E. Kiff Zeng Yi Jilin Medical College.Harverd School of Medicine,U.S.A.DETECTION OF IgG AND IgA ANTIBODIES TO EPSTEIN-BARR VIRUS EBNA-2A AND E8NA-LP IN SERA FROM PATIENTS WITH NA30PHA-RyNGEAL CARCINOMA AND FROM NORMAL INDIVIDUALS[J].Chinese Journal of Virology,1990,6(3):228-232. |
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| Authors: | Han Rujing F Huang E Kiff Zeng Yi Jilin Medical CollegeHarverd School of Medicine USA |
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| Affiliation: | Han Rujing F. Huang E. Kiff Zeng Yi Jilin Medical College.Harverd School of Medicine,U.S.A.Institute of Virology,Chinese Academy of Preventive Medicine. |
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| Abstract: | The Epstein-Barr virus nuclear antigen ( EBNA)is one of the main antigen expressed in latent infection. It is a component of different proteins. IgG and IgA antibodiss to EBNA-2A and EBNA-LP were detected in sera from NPC patients and from normal individuals by the indirect immuno-fluorescence test. Cells transfected with EBV genes expressing EBNA-2A or EBNA-LP were used as target cells. For IgG/EBNA-2A antibody 100% of NPC patients were positive with GMT 1 : 38.9 and 70% of normal individuals were positive with GMT 1:7.9 The positive rate and GMT of these two groups were significantly different. For IgG/EBNA-LP antibody. 87% of NPC patients were positive with GMT 1 :9.3 and 67% normal individuals were positive with GMT 1: 7.9. After removal of IgG antibodies with SPA, IgA/EBNA-2A and IgA/EBNA-LP were all negative in both NPC patients and in normal individuals. The result perhaps is due to non expression of EBNA-2A and EBNA-LP in NPC cancer cells. |
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| Keywords: | Nasopharyngeal carcinoma ( NPC ) EBV Nuclear Antigen |
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