商陆化学成分及药理作用和临床应用研究进展

商陆为《中国药典》收载品种,包括商陆Phytolacca acinosa与垂序商陆P.americana,具有重要的药用价值。商陆的特征性化学成分是三萜皂苷,此外还有黄酮、酚酸、甾醇、多糖等成分。现代药理学研究表明,商陆具有利尿、抗菌、抗病毒、抗炎、抗肿瘤等作用;临床上多用其治疗乙型肝炎、银屑病、过敏性紫癜等疾病。对商陆的化学成分、药理作用和临床疗效进行了总结,以期为商陆的开发利用及深入研究提供参考。

Research progress on chemical constituents, pharmacological effects, and clinical applications of Phytolaccae Radix

Phytolaccae Radix, including Phytolacca acinosa and P. Americana, is recorded by Chinese Pharmacopoeia for its important medicinal property. The most characteristic chemical constituents of Phytolaccae Radix are triterpenoid saponins, and there are also flavone, phenolic acid, sterol, and polysaccharides in it. Phytolaccae Radix has various pharmacological activities, such as diuretic, antibacterial, antiviral, anti-inflammation, anticancer effects, and so on, and it is usually used to treat hepatitis B, psoriasis, irritability, and so on. In this paper, we summarize the chemical composition, pharmacyological action, and clinical curative effect of Phytolaccae Radix to prompt the development and utilization of them.