哮喘—慢性阻塞性肺疾病重叠综合征患者76例临床特征

目的观察分析76例哮喘—慢性阻塞性肺疾病重叠综合征患者的临床特征。方法选取本院在2018年3月—2019年1月收治的76例哮喘—慢性阻塞性肺疾病重叠综合征患者(作为E组),再选取同期我院收治的76例哮喘患者(作为F组)和76例慢性阻塞性肺疾病患者(作为G组)。结果E组外周血嗜酸性粒细胞百分比、FEV 1% pred、FEV 1/FVC、Dm、FeNO低于F组(P<0.05),E组患者、G组患者血清总免疫球蛋白E升高所占比比较差异无统计学意义(P>0.05),E组患者血清总免疫球蛋白E升高所占比高于F组患者(P<0.05);E组RV/TLC高于F组患者(P<0.05),E组RV/TLC、Dm、FeNO高于G组(P<0.05)。结论哮喘—慢性阻塞性肺疾病重叠综合征患者与慢性阻塞性肺疾病患者相比而言具有较好的肺弥散功能,哮喘—慢性阻塞性肺疾病重叠综合征患者与哮喘患者相比而言肺弥散功能较差且肺通气功能降低。

Clinical Features of 76 Patients With Asthma-Copd Overlap Syndrome

Objective To observe and analyze the clinical characteristics of 76 patients with asthma-copd overlap syndrome.Methods 76 patients with asthma-copd overlap syndrome admitted to our hospital(from March 2018 to January 2019)were selected as group E,and 76 patients with asthma(as group F)and 76 patients with chronic obstructive pulmonary disease(as group G)admitted to our hospital during the same period were selected.The clinical characteristics of the three groups were analyzed by statistics.Results Group E in patients with peripheral eosinophil percentage,FEV 1% Mr Pred(percentage of forced expiratory volume in 1 s expected),FEV 1/FVC of forced vital capacity(1 s forced expiratory volume percentage)and Dm(alveolar capillary diffusion amount),FeNO(breath)CO concentration is lower than the group F patients group(P<0.05),There was no significant difference in the proportion of serum total immunoglobulin E in group E and group G(P>0.05).The proportion of serum total immunoglobulin E in group E was higher than that in group F(P<0.05),RV/TLC(percentage of residual volume and total lung volume)in group E was higher than that in group F(P<0.05),and RV/TLC,Dm and FeNO in group E were higher than that in group G(P<0.05).Conclusion Compared with patients with chronic obstructive pulmonary disease,patients with asthma-copd overlap syndrome have better pulmonary dispersion function,and patients with asthma-copd overlap syndrome have worse pulmonary dispersion function and lower pulmonary ventilation function.