Thermosensitive nanoparticles prepared from poly(N‐isopropylacrylamide‐acrylamide‐vinilpyrrolidone) and its blend with poly(lactide‐co‐glycolide) for efficient drug delivery system |
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| Authors: | Roya Salehi Soodabeh Davaran Mohammad R Rashidi Ali Akbar Entezami |
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| Affiliation: | 1. Laboratory of Polymer, Department of Organic Chemistry, Faculty of Chemistry, University of Taabriz, Tabriz, Iran;2. Department of Biomedical, Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Science, Tabriz, Iran;3. Department of Polymer Synthesis, Drug Applied Research Center, Tabriz University of Medical Science, Tabriz, Iran |
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| Abstract: | Temperature‐responsive polymers have become increasingly attractive as carrier for the injectable drug delivery systems. In the present work, we have studied the preparation of poly(N‐isopropylacrylamide‐acrylamide‐vinilpyrrolidone) (NIPAAm‐AAm‐VP terpolymer) nanoparticulated terpolymer and its blend with poly(lactide‐co‐glycolide, PLGA; molar ratio of lactide/glycolid 1/3). Thermosensitive terpolymer, poly(NIPAAm‐AAm‐VP) was prepared by free‐radical polymerization in aqueous solution. The nanoparticles of poly(NIPAAm‐AAm‐VP) and its blend with PLGA containing naltrexone were prepared using the evaporation and w/o emulsion‐solvent evaporation methods, respectively. Nanoparticles prepared from terpolymer‐PLGA blend at low polymer concentration (5%) shows larger particle size (>300 nm) and higher drug content%. Various types of nanoparticles showed a burst release of less than 10% after 24 h . The results suggest that by regulating different variables, desired release profiles of naltrexone can be achieved using a blend of PLGA‐poly(NIPAAm‐AAm‐VP) nanoparticulate system. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2009 |
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| Keywords: | thermosensitive nanoparticles poly(N‐isopropylacrylamide) poly(lactide‐co‐glycolide) blend naltrexone drug delivery |
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