| 革兰阴性杆菌对亚胺培南耐药率的变迁 |
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| 引用本文： | 郭普,乔艳,赵峰,李峰,郑晶,沈继龙.革兰阴性杆菌对亚胺培南耐药率的变迁[J].实用全科医学,2010,8(5):641-642. |
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| 作者姓名： | 郭普 乔艳 赵峰 李峰 郑晶 沈继龙 |
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| 作者单位： | 郭普(230032,安徽医科大学病原生物学教研室;233004,安徽省蚌埠医学院第一附属医院检验科);乔艳(安徽省蚌埠医学院第一附属医院感染病科,233004);赵峰(安徽省蚌埠医学院第一附属医院肿瘤外科一病区,233004);李峰,郑晶(安徽省蚌埠医学院第一附属医院检验科,233004);沈继龙(安徽医科大学病原生物学教研室,230032) |
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| 摘 要： | 目的调查革兰阴性杆菌对亚胺培南的耐药率变迁。方法收集2007年1月-2009年12月从蚌医附院患者各种临床标本中分离的革兰阴性杆菌,使用VITEK-32全自动微生物分析仪进行细菌鉴定和药敏试验,对结果进行回顾性分析。结果共分离出革兰阴性杆菌2256株,42个细菌种,肠杆菌科细菌1258株,占55.76%,非发酵菌751株,占33.29%,分离率前5位的病原菌分别是大肠埃希菌、鲍曼不动杆菌、铜绿假单胞菌、肺炎克雷伯菌和阴沟肠杆菌。肠杆菌科细菌对亚胺培南的耐药率较低,除聚团肠杆菌外,其他肠杆菌科细菌对亚胺培南的耐药率均〈10．00％，肺炎克雷伯菌6．94％和大肠埃希菌4．83％。嗜麦芽窄食单胞菌、鲍曼不动杆菌、铜绿假单胞菌、洛菲不动杆菌和荧光假单胞菌对亚胺培南的耐药率分别为100．00％、66．84％、35．29％、28．00％和25．00％。结论临床分离的革兰阴性杆菌以大肠埃希菌、鲍曼不动杆菌、铜绿假单胞菌为主，亚胺培南对肠杆菌科细菌具有非常强的体外抗菌活性，对非发酵菌的体外抗菌活性较差，铜绿假单胞菌、鲍曼不动杆菌、大肠埃希菌和肺炎克雷伯菌对亚胺培南的耐药率呈上升趋势。
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| 关 键 词： | 革兰阴性杆菌 亚胺培南 耐药率 |
Vicissitudes of Resistance to Imipenem in Gram-negative Bacilli |
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| GUO Pu,QIAO Yan,ZHAO Feng,et al..Vicissitudes of Resistance to Imipenem in Gram-negative Bacilli[J].Applied Journal Of General Practice,2010,8(5):641-642. |
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| Authors: | GUO Pu QIAO Yan ZHAO Feng |
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| Affiliation: | GUO Pu,QIAO Yan,ZHAO Feng,et al.Department of Laboratory Science,the First Affiliated Hospital of Bengbu Medical College,Bengbu 233004,Anhui,China |
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| Abstract: | Objective To investigate the vicissitudes of resistance to imipenem in Gram-negative bacilli isolated from clinical specimens.Methods Gram-negative bacilli were isolated from various clinical specimens in our hospital from Jan 2007 to Dec 2009.The identification and antimicrobial susceptibility test was determined by VITEK-32 full automated microbiology analyzer.The data were analyzed retrospectively.Results A total of 2 256 strains of Gram-negative bacilli were isolated including 42 species and 1 258 isola... |
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| Keywords: | Gram-negative bacilli Imipenem The resistant rates |
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