| 地西他滨治疗老年骨髓增生异常综合征1例并文献复习 |
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| 作者姓名： | Gao Y Ping B Zhou S |
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| 作者单位： | 南方医科大学南方医院惠侨科 |
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| 基金项目： | 国防科工委专项课题分题(B3320062101) |
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| 摘 要： | 骨髓增生异常综合征(MDS)表观遗传学改变和去甲基化药物的问世为其治疗提供了新的方向,用标准剂量地西他滨治疗IPSS分期中危Ⅱ的老年MDS患者1例,第一疗程即达完全缓解,取得较好效果,同时对地西他滨治疗MDS的国内外文献进行复习。
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| 关 键 词： | 骨髓增生异常综合征 DNA甲基化 地西他滨 |
Decitabine for treatment of myelodysplastic syndrome in an elderly patient and review of literature |
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| Gao Y,Ping B,Zhou S.Decitabine for treatment of myelodysplastic syndrome in an elderly patient and review of literature[J].Journal of Southern Medical University,2012,32(2):280-282. |
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| Authors: | Gao Ya Ping Baohong Zhou Shuyun |
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| Affiliation: | Huiqiao Department, Southern Medical University, Guangzhou, China. xiaoya_729@yahoo.com.cn |
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| Abstract: | Findings in epigenetic changes in meylodysplastic syndromes (MDS) and the development of demethylating drugs provide a new approach to the treatment of MDS. We used standard-dose decitabine for treatment of MDS in an elderly patient with an International Prostate Symptom Score (IPSS) of moderate risk group 2, and achieved a complete response in the first course. We report our experience with this case and review the relevant literatures. |
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| Keywords: | myelodysplastic syndromes DNA methylation decitabin |
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