| ^117Sn^m-DTPMP的制备及其在小鼠体内的生物分布 |
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| 引用本文： | 何佳恒,杨玉青,王关全,蒋树斌.^117Sn^m-DTPMP的制备及其在小鼠体内的生物分布[J].同位素,2009,22(2):76-80. |
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| 作者姓名： | 何佳恒 杨玉青 王关全 蒋树斌 |
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| 作者单位： | 中国工程物理研究院,核物理与化学研究所,四川,绵阳,621900 |
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| 基金项目： | 中国工程物理研究院军民两用基金 |
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| 摘 要： | 合成了具有亲骨性的氨基膦酸配体二乙基三胺基五亚甲基膦酸（DTPMP），制备了^117Sn^m（Ⅳ）-DTPMP，并研究其稳定性、亲脂性以及在小鼠体内的生物分布。结果表明，^117Sn^m（Ⅳ）-DTPMP的制备方法简单，稳定性好，亲水，标记率〉95％；在小鼠体内的生物分布表明，^117Sn^m（Ⅳ）-DTPMP的靶向摄取率即骨摄取率较高，注射1h之后达（22．26±2．02）％ID／g，是一种极具潜力的新型放射性药物。
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| 关 键 词： | ^117Sn^m DTPMP 生物分布 |
Preparation and Biodistribution of 117Snm-DTPMP |
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| HE Jia-heng,YANG Yu-qing,WANG Guan-quan,JIANG Shu-bin.Preparation and Biodistribution of 117Snm-DTPMP[J].Isotopes,2009,22(2):76-80. |
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| Authors: | HE Jia-heng YANG Yu-qing WANG Guan-quan JIANG Shu-bin |
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| Affiliation: | (Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mian yang 621900, China) |
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| Abstract: | DTPMP Triethyleneteraamine Hexa（Methylene Phosphonic Acid）] was synthesized and radiolabeled with ^117Sn^m. The preparation conditions, stability and lipophilieity of ^117Sn^m（Ⅳ）-DTPMP were investigated. Biodistribution of ^117Sn^m（Ⅳ）-DTPMP in mice was studied. It was found that the quantity of DTPMP and pH of the preparation solution had vital effects on the labeling yield of ^117Sn^m（Ⅳ）-DTPMP, and ^117Sn^m（Ⅳ）-DTPMP was hydrophilic and stable at room temperature and 37 ℃ in open air. The animal study showed that ^117Sn^m（Ⅳ）-DTPMP had high bone uptake and bone-to-blood ratio in the mice, which is higher than that of ^117Sn^m（Ⅳ）-DTPA and reached （22.26±2.02）%ID/g at 1 h. This made it potentially useful as an reagent for skeletal scintigraphy and radiotherapy of bone tumors. |
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| Keywords: | 117Snm DTPMP |
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