| 钙及活性氧在大鼠肾缺血再灌流损伤中的作用 |
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| 引用本文： | 沙继宏,叶煦亭,吴莉丽,吴越,杨勇骥,郑尊.钙及活性氧在大鼠肾缺血再灌流损伤中的作用[J].中国病理生理杂志,2000,16(6):531-533. |
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| 作者姓名： | 沙继宏 叶煦亭 吴莉丽 吴越 杨勇骥 郑尊 |
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| 作者单位： | 第二军医大学细胞生物学教研室,上海,200433 |
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| 摘 要： | 目的和方法 :应用电镜细胞化学方法 ,对缺血 -再灌流损伤过程中活性氧的产生及细胞内钙变化情况进行研究。结果 :缺血期 ,细胞内钙明显增多 ,而此时尚无H2 O2 产生 ;缺血后再灌流早期H2 O2 大量产生 ,细胞内钙与缺血期类似 ;再灌流晚期H2 O2 产生有所减少 ,而细胞内钙持续增高。结论 :钙及活性氧都参与缺血再灌流损伤 ,但其参与时机及作用并不相同。
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| 关 键 词： | 局部缺血 再灌注 钙 氧 |
The effects of calcium and reactive oxygen species in rat kidney during ischemia and reperfusion period |
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| SHA Ji-hong,YE Xu-ting,WU Li-li,WU Yue,YAN Yong-ji,ZHEN Zun.The effects of calcium and reactive oxygen species in rat kidney during ischemia and reperfusion period[J].Chinese Journal of Pathophysiology,2000,16(6):531-533. |
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| Authors: | SHA Ji-hong YE Xu-ting WU Li-li WU Yue YAN Yong-ji ZHEN Zun |
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| Affiliation: | SHA Ji-hong, YE
Xu-ting, WU Li-li, WU Yue, YAN Yong-ji, ZHEN Zun
(Department of Basic Medicine, Second Military Medical University, Shanghai 200433, China) |
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| Abstract: | AIM and METHODS: Electron cytochemical methods were used to study the changes of calcium and reactive oxygen species in rat kidney during ischemia and reperfusion period.RESULTS:By the end of 1h ischemia, intra-cellular calcium increased. There were no H 2O 2 generation at this time. In the early reperfusion period, large amount of H 2O 2 generated. At this time, there were no evident changes of intra-cellular calcium compare with 1h ischemia group. In the later reperfusion period, less H 2O 2 generated. Intra-cellular calcium increased continuously.CONCLUSION:Calcium and reactive oxygen species all participated in ischemia-reperfusion injury, but the time they participated and their effects were different. |
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| Keywords: | Ischemia Reperfusion Calcium Oxygen |
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