| 咖啡酸苯乙酯固体分散体的制备 |
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| 引用本文： | 王兰,张德辉,沈文,龚频,庞赞明,孙蕊,敖芬.咖啡酸苯乙酯固体分散体的制备[J].中成药,2019(1):12-15. |
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| 作者姓名： | 王兰 张德辉 沈文 龚频 庞赞明 孙蕊 敖芬 |
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| 作者单位： | 1.陕西科技大学 |
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| 基金项目： | 陕西省缺血性心血管疾病重点实验室开放基金(2016ZDKF-05);陕西省科技厅一般项目-农业领域(2017NY-103);陕西省自然科学基础研究计划项目(2017JM8079) |
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| 摘 要： | 目的制备咖啡酸苯乙酯固体分散体。方法以PVP K30为载体,溶剂法制备固体分散体;以咖啡酸苯乙酯溶解度、溶出度为评价指标,筛选药物(咖啡酸苯乙酯)-载体(PVP K30)比例。然后,通过透射电镜(SEM)、差示扫描量热(DSC)、X射线衍射(XRD)对固体分散体进行鉴定分析。结果药物-载体比例为1∶10时,咖啡酸苯乙酯溶解度、溶出度最高,并以无定形状态分散在载体中。结论固体分散体技术可明显提高咖啡酸苯乙酯溶解度、溶出度。
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| 关 键 词： | 咖啡酸苯乙酯 固体分散体 制备 溶剂法 |
Preparation of caffeic acid phenethyl ester solid dispersions |
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| WANG Lan,ZHANG De-hui,SHEN Wen,GONG Pin,PANG Zan-ming,SUN Rui,AO Fen.Preparation of caffeic acid phenethyl ester solid dispersions[J].Chinese Traditional Patent Medicine,2019(1):12-15. |
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| Authors: | WANG Lan ZHANG De-hui SHEN Wen GONG Pin PANG Zan-ming SUN Rui AO Fen |
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| Affiliation: | (Shaannxi University of Science and Technology,Xi’an 710021,China) |
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| Abstract: | AIM To prepare caffeic acid phenethyl ester solid dispersions. METHODS For the solid dispersions prepared by solvent method with PVP K30 as a carrier,drug( caffeic acid phenethyl ester)-carrier( PVP K30) ratio was screened with the solubility and dissolution rates of caffeic acid phenethyl ester as evaluation indices. Subsequently,scanning electron microscope( SEM),differential scanning calorimetry( DSC) and X-ray diffraction( XRD) were adopted in the identification and analysis of solid dispersions. RESULTS Dispersed in an amorphous state,caffeic acid phenethyl ester demonstrated the highest solubility and dissolution rates at the drugcarrier ratio of 1 ∶ 10. CONCLUSION Solid dispersion technology can obviously improve the solubility and dissolution rates of caffeic acid phenethyl ester. |
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| Keywords: | caffeic acid phenethyl ester solid dispersions preparation solvent method |
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