俯卧位通气联合雾化吸入治疗AECOPD的临床效果

目的观察俯卧位通气治疗AECOPD的临床效果。方法选取2015年10月～2017年5月转入ICU的AE COPD患者60例为研究对象,将其随机分成两组,其中实验组30例,给予俯卧位通气联合雾化吸入;对照组30例,给予仰卧位通气联合雾化吸入。监测动脉血氧分压(PaO_2)、动脉血二氧化碳分压(PaCO_2),氧合指数(PaO_2/FiO_2),生命体征进行监测;监测感染指标包括白细胞计数(WBC)、降钙素原(PCT)、患者痰液量和性状变化。结果两组间PaO_2、PaO_2/FiO_2比较差异有统计学意义(P0.05);两组间WBC、PCT、痰液引出量比较差异有统计学意义(P0.05);两组有创呼吸机使用时间、ICU住院时间比较差异有统计学意义(P0.05)。结论俯卧位通气在改善AECOPD患者氧合、加速痰液引流方面优于仰卧位通气,有创呼吸机使用时间和ICU住院日有所缩短。

Clinical effect of prone position ventilation combined with aerosol inhalation in the treatment of AECOPD

Objective To observe the clinical effect of prone position ventilation in the treatment of AECOPD.Methods?60 patients with AECOPD who were transferred to the ICU from October 2015 to May 2017 were enrolled and randomly divided into the experimental group of 30 patients who were given the prone position ventilation combined with aerosol inhalation,and the control group of 30 patients who were given supine position ventilation combined with aerosol inhalation.The arterial oxygen partial pressure(PaO2),arterial blood carbon dioxide partial pressure(PaCO2),oxygenation index(PaO2/FiO2),vital signs and the infection indicators including white blood cell count(WBC),procalcitonin(PCT),the changes of patients sputum volume and traits were monitored between the two groups.Results?There were statistically significant differences in PaO2and PaO2/FiO2between the two groups(P<0.05).The differences in WBC,PCT and sputum extraction were statistically significant between the two groups(P<0.05).There were statistically significant differences in the inoperative ventilator use time and ICU hospitalization time between the two groups(P<0.05).Conclusion?Prone position ventilation is superior to supine position ventilation in improving oxygenation and accelerating sputum drainage in patients with AECOPD.And in the former case,the use time of invasive ventilator and ICU hospitalization day are shortened.