| 氮唑取代苯基醚类衍生物的合成及其抗真菌活性 |
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| 引用本文： | 程潜,李长荣.氮唑取代苯基醚类衍生物的合成及其抗真菌活性[J].中国药物化学杂志,1997,7(2):97-102. |
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| 作者姓名： | 程潜 李长荣 |
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| 作者单位： | [1]中国医学科学院北京协和医科大学药物研究所 [2]中国农业大学应用化学系 |
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| 摘 要： | 通过取代溴苄与１－（２，４－二取代苯基）－２－（１Ｈ－吲哚和苯并咪唑－１－基）乙醇反应，合成了一系列１－｛２－「（取代苯基）甲基」－２－（取代苯基）乙基－１－吲哚和苯并咪唑类新化合物，并用二倍体稀释法对化合物进行了体外抗真菌试验。
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| 关 键 词： | 氮唑类化合物 合成 抗真菌活性 |
Synthesis and Antifungal Activity of N Azole Substituted Phenyl Ether Derivatives |
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| Cheng Qian,Liu Xiaohui.Synthesis and Antifungal Activity of N Azole Substituted Phenyl Ether Derivatives[J].Chinese Journal of Medicinal Chemistry,1997,7(2):97-102. |
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| Authors: | Cheng Qian Liu Xiaohui |
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| Abstract: | New compounds of 1 {2 (substituted phenyl)methoxyl 2 (substituted phenyl)ethyl} 1 H indoles and benzimidazoles have been designed and synthesized.All of them have been confirmed by spectrum methods(IR, 1HNMR,MS)and elementary analysis. The preliminary antifungal tests were carried out in vitro and the results showed that some of them had good activity against 9 species of fungi( Microsprum Canis,Trichophyton rubrum etc.) |
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| Keywords: | indole benzimidazole antifungal activity |
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