| 人-鼠抗CD4嵌合抗体的生物学效应研究 |
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| 引用本文： | 朱慧芬,杨道锋,王晓林,朱志刚,张悦,沈关心.人-鼠抗CD4嵌合抗体的生物学效应研究[J].中华器官移植杂志,2000,21(2):92-94. |
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| 作者姓名： | 朱慧芬 杨道锋 王晓林 朱志刚 张悦 沈关心 |
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| 作者单位： | 1. 同济医科大学免疫学教研室,武汉,430030
2. 同济医科大学附属同济医院传染科 |
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| 基金项目： | 国家自然科学基金!393870 6 2 8 |
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| 摘 要： | 目的 探讨人－鼠抗ＣＤ４嵌合抗体的生物学效应，方法 观察ＣＤ４人－鼠嵌合抗体和鼠源性单抗对ＣＤ３，植物血凝素（ＰＨＡ），白细胞－２（ＩＬ－２）及同种异体细胞诱导增殖的影响，以及介导的抗体依赖性细胞介导的细胞毒性（ＡＤＣＣ）作用。结果 提示ＣＤ４嵌合抗体和鼠源性ＣＤ４抗体对以上几种诱导剂诱导的增殖均有抑制作用，且抗体剂量越大，抑制作用越强。
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| 关 键 词： | CD4嵌合抗体 增殖抑制 生物学效应 移植免疫学 |
The biological effect of anti-CD4 human-mouse chimeric antibody |
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| ZHU Huifen,YANG Daofen,WANG Xiaolin,et al..The biological effect of anti-CD4 human-mouse chimeric antibody[J].Chinese Journal of Organ Transplantation,2000,21(2):92-94. |
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| Authors: | ZHU Huifen YANG Daofen WANG Xiaolin |
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| Affiliation: | ZHU Huifen,YANG Daofen,WANG Xiaolin,et al. Department of Immunology,Tongji Medical University,Wuhan 430030,China |
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| Abstract: | Objective To investigate the biological effect of anti CD4 human mouse chimeric antibody. Methods The effects of anti CD4 human mouse chimeric and mouse derived monoclonal antibody on CD3, PHA, IL 2, proliferation induced by allogenic cells and the propagation of ADCC mediated by these antibodies were observed. Results The propagation of PBMC induced by CD3, PHA, IL 2 and allogenic cells was inhibited by both the chimeric antibody and mouse monoclonal antibody with the inhibitory activity being directly proportional to the dosage of the antibodies. With a given dosage, the inhibitory activity induced by the chimeric antibody was higher than that by the mouse antibody. Conclusion The killing action of PBMC to cultured tumor cells could be promoted by both antibodies. |
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| Keywords: | Anti CD4 chimeric antibodies Propagation inhibition |
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