| 甲丙氨酯的合成 |
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| 引用本文： | 叶瑾亮,张小春,陈伟健.甲丙氨酯的合成[J].广东化工,2008,35(9). |
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| 作者姓名： | 叶瑾亮 张小春 陈伟健 |
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| 作者单位： | 广东省化学工业公共实验室,广东省石油化工研究院,广东,广州,510665 |
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| 摘 要： | 把2-甲基-2-丙基-1,3-丙二醇和无水氰酸钠加入到氯仿中,在低温的条件下,连续通入干燥氯化氢气体进行酯化反应,得到2-甲基-2-丙基-1,3-丙二醇二氨基甲酸酯(甲丙氨酯),用热水重结晶,收率达85%.当把无水氰酸钠改为分三次投料时,收率提高到93%.并通过IR和HNMR,对目标产物进行了表征.
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| 关 键 词： | 2-甲基-2-丙基-1 3-丙二醇二氨基甲酸酯 甲丙氨酯 氰酸钠 合成 |
Preparation of Meprobamate |
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| Ye Jinliang,Zhang Xiaochun,Chen Weijian.Preparation of Meprobamate[J].Guangdong Chemical Industry,2008,35(9). |
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| Authors: | Ye Jinliang Zhang Xiaochun Chen Weijian |
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| Abstract: | 2-methyl-2-propyl-1,3-propanediol and anhydrous sodium cyanate were added in chloroform,with low temperiture condiction,dry gaseous hydrochloride were inlet to perform esterification reaction,giving 2-methyl-2-propyl-1,3-propanediol dicarbamate(meprobamate),with a yield of 85 % after recrystallization from hot water.When anhydrous sodium cyanate were added in three batches,the yield rose up to 93 %.The titled compound were characterized by IR and HNMR. |
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| Keywords: | 2-methyl2-propyl-1 3-propanediol meprobamate sodium cyanate preparation |
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