| 甲基叔丁基醚、无水乙醇、碳酸二甲酯的致突变性 |
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| 引用本文： | 宋崇林,高祥,成存玉,刘克明,周蕾,赵春红.甲基叔丁基醚、无水乙醇、碳酸二甲酯的致突变性[J].天津大学学报(自然科学与工程技术版),2004,37(8):678-681. |
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| 作者姓名： | 宋崇林 高祥 成存玉 刘克明 周蕾 赵春红 |
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| 作者单位： | 天津大学内燃机国家重点实验室，天津大学内燃机国家重点实验室，天津大学内燃机国家重点实验室，天津市卫生防病中心，天津市卫生防病中心，天津市卫生防病中心 天津300072，天津300072，天津300072，天津300011，天津300011，天津300011 |
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| 基金项目： | 国家自然科学基金资助项目(50076032);天津市自然科学基金资助项目(003604511). |
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| 摘 要： | 评价和比较了3种汽油增氧剂甲基叔丁基醚(MTBE)、无水乙醇(AE)和碳酸二甲酯(DMC)的致突变性.采用Ames实验研究3种汽油增氧剂的致突变性;采用小鼠睾丸染色体畸变实验检测3种汽油增氧剂对小鼠睾丸染色体的致畸作用.Ames实验的阴性结果表明,在本实验条件下,未发现MTBE、AE、DMC具有致突变性.在小鼠睾丸染色体畸变实验中,虽然实验结果为阴性,但随着MTBE剂量的增加,染色体分离有增加趋势,表明其可能存在遗传毒性.
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| 关 键 词： | 汽油增氧剂 Ames实验 小鼠睾丸染色体畸变实验 致突变性 |
| 文章编号： | 0493-2137(2004)08-0678-04 |
| 修稿时间： | 2003年12月12 |
Mutagenicity of Methyl Tertiary-Butyl Ether, Anhydrous Ethanol and Dimethyl Carbonate |
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| SONG Chong-lin,GAO Xiang,CHENG Cun-yu,LIU Ke-ming,ZHOU Lei,ZHAO Chun-hong anjin ,China, .Centre for Disease Control and Prevention,Tianjin ,China.Mutagenicity of Methyl Tertiary-Butyl Ether, Anhydrous Ethanol and Dimethyl Carbonate[J].Journal of Tianjin University(Science and Technology),2004,37(8):678-681. |
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| Authors: | SONG Chong-lin GAO Xiang CHENG Cun-yu LIU Ke-ming ZHOU Lei ZHAO Chun-hong anjin China Centre for Disease Control and Prevention Tianjin China |
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| Affiliation: | SONG Chong-lin~1,GAO Xiang~1,CHENG Cun-yu~1,LIU Ke-ming~2,ZHOU Lei~2,ZHAO Chun-hong~2 anjin 300072,China, 2.Centre for Disease Control and Prevention,Tianjin 300011,China) |
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| Abstract: | In Ames test, the mutagenicity of three kinds of gasoline oxygenates (methyl tertiary-butyl ether (MTBE), anhydrous ethanol (AE) and dimethyl carbonate (DMC)) was evaluated and compared, in the experiments three dosage levels of 5.0 mg/plate, 2.5 mg/plate and original liquid with and without the addition of metabolic enzymes (S9) were used respectively. Meanwhile, the mice testicle cells chromosome aberration test was employed respectively to detect the teratogenicity of three gasoline oxygenates with contamination dosage levels of 1/8, 1/4 and 1/2 of LD_(50) . The negative results of Ames test showed that there was no detection of the mutagenicity in MTBE, AE and DMC under the conditions of this experiment. In the mice testicle cells chromosome aberration test, although the results were negative, the segregation of chromonemas increased with the rise of concentration of MTBE, which indicated that MTBE may have the genotoxicity. |
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| Keywords: | gasoline oxygenate Ames test mice testicle cells chromosome aberration test mutagenicity |
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