| 北方汉族人PLA2R1基因多态性与脑梗死关系的研究 |
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| 引用本文： | 王凤,吴江,杜丹华,高鹏.北方汉族人PLA2R1基因多态性与脑梗死关系的研究[J].中风与神经疾病杂志,2006,23(6):711-713. |
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| 作者姓名： | 王凤 吴江 杜丹华 高鹏 |
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| 作者单位： | 1. 吉林大学第一医院神经内科,吉林,长春,130021
2. 吉林大学第一医院内分泌科,吉林,长春,130021 |
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| 摘 要： | 目的探讨中国北方汉族人群PLA2R1基因多态性与脑梗死的关系。方法选取年龄、性别匹配的中国北方汉族脑梗死患者212人,健康对照组179人,采用PCR技术和限制性内切酶片段长度多态性(RFLP)的方法检测基因型。结果PLA2R1基因SNP的等位基因和基因型在脑梗死组和对照组的频数分布差异无显著性(P>0.05)。结论中国北方汉族人群中PLA2R1基因多态性与脑梗死的发病可能无关。
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| 关 键 词： | PLA2R1 脑梗死 基因多态性 限制性片段长度 |
| 文章编号： | 1003-2754(2006)06-0711-03 |
| 收稿时间： | 2006-09-20 |
| 修稿时间： | 2006-11-20 |
Association between PLA2R1 gene polymorphism and cerebral infarction |
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| WANG Feng, WU jiang, DU Dan Hua ,et al..Association between PLA2R1 gene polymorphism and cerebral infarction[J].Journal of Apoplexy and Nervous Diseases,2006,23(6):711-713. |
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| Authors: | WANG Feng WU jiang DU Dan Hua |
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| Affiliation: | Department of Neurology,The First Hospital of Jilin University,Changchun 130021 ,China |
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| Abstract: | Objective To investigate the genetic association between the PLA2R1 gene polymorphism and cerebral infarction in the Han descent population in the North of China.Methods APCR-based RFLP procedure was employed to detect the gene types of 212 patientes of Han descent population in the North of China.Results No significant differences were found in the frequencies of allele and genotype of SNP of PLA2R1 gene between the case and the control(P>0.05).Conclusion There is no genetic association between the PLA2R1 gene polymorphism and cerebral infarction in the Han descent population in the North of China. |
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| Keywords: | PLA2R1 Cerebral infarction Gene polymorphism Restriction fragment length |
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