| 治疗产ESBLs细菌感染的研究进展 |
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| 引用本文： | 贺毅,陆坚.治疗产ESBLs细菌感染的研究进展[J].国外医药(抗生素分册),2012,33(4):145-150,192. |
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| 作者姓名： | 贺毅 陆坚 |
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| 作者单位： | 贺毅 (广东医学院附属深圳市第三人民医院,深圳,518112) ； 陆坚 (广东医学院附属深圳市第三人民医院,深圳,518112) ； |
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| 摘 要： | 超广谱β-内酰胺酶(extended specturn β-lactamerses,ESBLs)是丝氨酸蛋白酶的衍生物,它能够水解青霉素类、广谱及超广谱头孢菌素类和单环β-内酰胺类抗生素,是革兰阴性细菌对抗生素耐药性产生的重要机制。产ESBLs细菌常具有对氨基糖苷类、喹诺酮类等抗菌药物的多重耐药,给临床抗感染治疗带来严峻挑战。本文就近年来治疗产ESBLs细菌感染的研究进展作一综述,以期为临床有效合理使用抗菌药物提供参考。
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| 关 键 词： | 超广谱β-内酰胺酶(ESBLs) 抗生素 抗感染治疗 |
Recent Progress on Treatment of Infections Caused by Bacteria Producing ESBLs |
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| He Yi,Lu Jian.Recent Progress on Treatment of Infections Caused by Bacteria Producing ESBLs[J].world notes on antibiotics,2012,33(4):145-150,192. |
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| Authors: | He Yi Lu Jian |
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| Affiliation: | ( The Third People＇s Hospital of Shenzhen Affiliated to Guangdong Medical College, Shenzhen 518112 ) |
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| Abstract: | The extended-spectrum β-lactamases （ESBLs） is a derivative of serine protease, it is able to hydrolyze penicillins, broad-spectrum and extended-spectrum cephalosporins and monocyclic β-lactamase antibiotics, and it is an important antibiotic resistance mechanism of gram-negative bacteria. Bacteria producing ESBLs often have multiple resistance to aminoglycosides, fluoroquinolones, it pose serious challenges to the clinical anti-infection therapy. This article summarizes about recent progress on treatment of infections caused by bacteria producing ESBLs, in order to provide references on clinical effectiveness and rational use of antibiotics. |
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| Keywords: | extended-spectrum β -lactamases （ESBLs） antibiotics anti-infection therapy |
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