肾移植患者术后早期小剂量应用抗胸腺淋巴细胞球蛋白的临床经验

为了观察抗胸腺淋巴细胞球蛋白（ＡＴＧ）的免疫抑制效果，将肾移植术后单独应用环孢素Ａ（ＣｓＡ）和术后早期小剂量应用ＡＴＧ的各２００例患者作了比较，结果ＣｓＡ组发生急性排斥反应（ＡＲ）４６例次（２３％），逆转４１例（８９．１％）；ＡＴＧ组发生ＡＲ３３例（１６．５％），逆转３１例（９３．９％）。肾功能在２～１０天恢复正常的，ＣｓＡ组为８４例（４２％），ＡＴＧ组为１５９例（７９．５％）；肾移植后合并感染，ＣｓＡ组３６例，ＡＴＧ组１８例；ＣｓＡ组摘肾８例，ＡＴＧ组４例；ＣｓＡ组死亡５例，ＡＴＧ组３例。本组资料提示小剂量ＡＴＧ的应用对延长肾移植后存活时间有重要意义

The application of small dose of anti-thymocyte globulin to 200 cadaveric kidney transplant recipients in early postoperative period

Presented in this study was the report of 200 cases treated with CsA and 200 caseswith small dose of anti-thymocyte globulin(ATG)in early postoperative period after kidney trans-plantation for the prevention of acute rejection.It was found that acute rejection occurred in 46case-times(23%)and 41 cases(89.1%)were reversed in CsA group.In ATG group,33 cases(16.5%)was diagnosed having acute rejection and 31 cases(93.9%)were reversed.84 case-times(42%)in CsA group and 159 case-times(79.5%)in ATG group showed recovery of kidneyfunction 2-10 days after the operation.18 cases in ATG group and 36 in CsA group were associat-ed with infection after kidney transplantation.The graft had to be extirpated in 4 of ATG groupand 8 of CsA group.3 had died in ATG and 5 in CsA.It was suggested that the application ofsmall dose of ATG might prolong the survival of transplanted kidney.