国产重组乙型肝炎疫苗(中国仓鼠卵巢细胞)免疫后1～8年效果观察

目的观察新生儿接种国产重组乙型肝炎(乙肝)疫苗中国仓鼠卵巢细胞(CHO细胞)]后1~8年免疫效果。方法2005年9~10月在4个试点乡对1997~1999年出生的儿童全部采集血清标本,检测乙肝病毒表面抗原(HBsAg)、乙肝病毒表面抗体(抗-HBs)和乙肝病毒核心抗体(抗-HBc)。结果免疫后1~8年,抗-HBs阳性(S/N≥2.1)率平均为91.95%,有效抗-HBs阳性(S/N≥10.0)率为75.74%,抗体S/N值几何平均浓度(GMC)为30.14毫国际单位/毫升。总的趋势是抗体阳性率和GMC随免疫年限延长逐渐降低。HBsAg阳性率为0.67%,抗-HBc阳性率为1.39%,未见HBsAg随免疫年限延长而逐渐升高的现象。结论国产重组乙肝疫苗(CHO细胞)免疫后1~8年抗体持久性下降,但保护效果良好。

Investigation on Immune Effects of Homemade Recombinant Hepatitis B Vaccine (CHO) After 1-8 years Inoculation

Objective To investigate immune effect of homemade recombinant Hepatitis B vaccine to new born baby after inoculating 1-8 years. Methods Based on the investigation of short-term effect of inoculating to new born baby with recombinant Hepatitis B vaccine(CHO),the serum samples of all children born from 1997 to 1999,who live in 4 villages of 7 experimental villages,were collected.HBsAg,anti-HBc and anti-HBs were detected by ELISA.Results After 8 years inoculating,the average positive rate of antiHBs is 91.95%.The effective positive rate of anti-HBs is 75.74%.The geometry mean concentration(GMC) of S/N of anti-HBs is 30.14.The general tendency is that the GMC and positive of anti-HBs descend gradually with the prolongation of time.In this study,HBsAg and anti-HBc positive rates are 0.67%,1.39% respectively.No ascent was found.Conclusion Both the protection efficacy and persistence of anti-HBs of homemade recombinant Hepatitis B vaccine(CHO) are very well to new born baby after 1-8 years inoculating.