初级纤毛在骨组织力学信号传导中的作用

骨组织不断接受力学刺激并保持骨形成和骨吸收的动态平衡。目前，人们仍不清楚骨组织如何感知力学刺激。越来越多的研究表明初级纤毛可能是骨组织力学刺激感受器，并将细胞外的力学刺激信号转化为细胞内的生化信息，最终骨组织实现其结构的重塑。在此，本文将对初级纤毛研究现状进行综述，并预测初级纤毛未来的研究趋势, 为利用初级纤毛来防治骨质疏松症打下基础。

The role of primary cilium in bone tissue mechanotransduction

Bone tissues constantly receive the mechanical stimulation and maintain the dynamic balance of bone formation and resorption. Currently, the mechanism of how bone tissues sense the mechanical stimulation is still unknown. An increasing number of studies have shown that primary cilium may be the mechanical sensor of bone tissues. The primary cilium maybe transfer the extracellular mechanical signals into intracellular biochemical message through them, and the mechanical stimulation received by bone tissues can regulate bone remodeling finally. This article reviews the current researches on primary cilium, predicts the research tendency and tries to lay some foundation for the use of primary cilium to prevent and treat osteoporosis.