| 对双胍基苯甲酰化壳聚糖盐酸盐的制备及其抗菌活性研究 |
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| 引用本文： | 金绍娣,高兆昶,刘德驹.对双胍基苯甲酰化壳聚糖盐酸盐的制备及其抗菌活性研究[J].日用化学工业,2011,41(3). |
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| 作者姓名： | 金绍娣 高兆昶 刘德驹 |
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| 作者单位： | 1. 盐城纺织职业技术学院化学工程系,江苏盐城224003;盐城工学院化学与生物工程学院,江苏盐城224005
2. 盐城纺织职业技术学院化学工程系,江苏盐城,224003 |
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| 基金项目： | 盐城工学院省应用化学重点学科建设基金资助项目(XKY2009005) |
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| 摘 要： | 在盐酸溶液中,对氨基苯甲酸与双氰胺反应合成了中间体对双胍基苯甲酸盐酸盐;该中间体再与氯化亚砜反应得双胍基苯甲酰氯。后者在甲磺酸体系中与壳聚糖进行酰化反应制得对双胍基苯甲酰壳聚糖盐酸盐。考察了酰化时间、温度及反应物投料比等对壳聚糖衍生物取代度的影响,并采用UV,IR,1HNMR对产物进行了表征。抗菌实验表明,该产物对大肠杆菌、金黄色葡萄球菌最低抑菌浓度分别为0.016和0.008 mg/mL,其抗菌活性优于壳聚糖和对双胍基苯甲酸盐酸盐,且随浓度的增大而增强。
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| 关 键 词： | 对双胍基苯甲酰壳聚糖盐酸盐 对双胍基苯甲酸盐酸盐 壳聚糖 抗菌活性 |
Synthesis and antibacterial activitiy of p -biguanido benzoyl chitosan hydrochloride |
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| JIN Shao-di,GAO Zhao-chang,LIU De-ju.Synthesis and antibacterial activitiy of p -biguanido benzoyl chitosan hydrochloride[J].China Surfactant Detergent & Cosmetics,2011,41(3). |
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| Authors: | JIN Shao-di GAO Zhao-chang LIU De-ju |
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| Affiliation: | JIN Shao-di1,2,GAO Zhao-chang1,LIU De-ju1(1.Department of Chemistry Engineering,Yancheng Textile Vocational Technology,Yancheng,Jiangsu 224003,China,2.School of Chemical and Biological Engineering,Yancheng Institute of Technology,Jiangsu 224005,China) |
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| Abstract: | The intermediate 1-(p-carboxyphenyl) biguanidine hydrochloride(p-CPBGH) was synthesized by p-aminobenzoic acid(PABA) as raw material,reacting with dicyandiamide in the presence of hydrochloric acid.Then p-CPBGH was reacted with thionyl chloride forming p-biguanido benzoyl chloride.The latter was reacted with chitosan in methylsulfonic acid as the reaction medium forming p-biguanido benzoyl chitosan hydrochloride(p-BGBCH).Effects of reaction time,reaction temperature and molar ratio of chitosan to p-CPBGH on... |
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| Keywords: | p-biguanido benzoyl chitosan hydrochloride 1-(p-carboxyphenyl) biguanidine hydrochloride chitosan antibacterial activity |
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