甘芍胶囊治疗耐克罗米芬性多囊卵巢综合征的临床研究 |
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引用本文: | 王治鸿,杨燕生,张永洛.甘芍胶囊治疗耐克罗米芬性多囊卵巢综合征的临床研究[J].中国中西医结合杂志,2005,25(8):704-706. |
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作者姓名: | 王治鸿 杨燕生 张永洛 |
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作者单位: | 1. 山西医科大学第一医院,太原,030001 2. 山西医科大学第二医院 |
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摘 要: | 目的评价甘芍胶囊(GSC)治疗耐克罗米芬(CC)、高雄激素血症多囊卵巢综合征(PCOS)患者的有效性、安全性,探索停药后CC改善促排卵效果的可行性。方法给27例PCOS患者服GSC,共8周(2个月经周期)。服药前、服药4周及8周末,观察血清生殖激素、体重指数(BMI)、盆腔超声相的变化及不良反应。停药后,将血清睾酮(T)〈(2.1±0.8)nmol/L的未排卵者再行CC促排卵,监测卵泡发育及效果。结果服药4周末,血清生殖激素均有显著变化。服药8周末,双侧卵巢体积、卵泡数及卵泡直径均显著减小,子宫内膜明显变薄。停中药2个月内,27例中6例自然排卵,2例自然妊娠。19例37个周期行CC促排卵,17例25个周期排卵,7例妊娠,排卵率89.5%,排卵周期率67.6%,妊娠率36.8%,妊娠周期率28.0%。结论采用GSC治疗耐CC、高雄激素血症PCOS患者,可使子宫内膜、卵巢形态及BMI得到明显改善,并提高耐CC者对CC促排卵的敏感性.
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关 键 词: | 多囊卵巢综合征 耐克罗米芬 高雄激素血症 甘芍胶囊 克罗米芬 临床研究 治疗 胶囊 促排卵效果 血清生殖激素 |
收稿时间: | 2004-12-29 |
修稿时间: | 2005-05-20 |
Clinical Study of Ganshao Capsule in Treating Clomiphene-resistant Polycystic Ovarian Syndrome |
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Authors: | WANG Zhi-hong YANG Yan-sheng ZHANG Yong-luo |
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Abstract: | OBJECTIVE: To assess the efficacy and safety of Ganshao Capsule (GSC) in treating clomiphene (CC)-resistant hyperandrogenemic polycystic ovarian syndrome (PCOS), and to explore the feasibility of using CC for improving ovulation induction after withdrawal of GSC. METHODS: Twenty-seven PCOS patients were given GSC for 8 weeks (2 cycles). Changes in serum reproductive hormone, body mass index (BMI), adverse reaction, as well as pelvic ultrasonographic feature were observed before treatment, at the end of 4 weeks and 8 weeks after treatment. After stopping GSC medication, CC was used to induce ovulation in patients whose serum testosterone (T) < (2.1+/-0.8) nmol/L but without ovulation. Condition of follicle growth and effect of GSC were monitored. RESULTS: After 4 weeks of treatment, serum reproductive hormones were significantly changed. At the end of 8 weeks, bilateral ovarian volume, number of follicles, and diameter of follicles were significantly reduced, and endometrium obviously thinned. Within 2 months after stopping medication, 6 in the 27 patients got natural ovulation, and 2 natural pregnancy. In the other 19 patients who received ovulation induction during the 37th cycles, 17 had ovulation in the 25th cycles, 7 got pregnancy, the ovulation rate being 89.5%, ovulation cycle rate 67.6%, pregnant rate 36.8%, and pregnant cycle rate 28.0%. CONCLUSION: Endometrium, ovarian morphology and BMI got significant improvement in PCOS patients with CC- resistance and hyperandrogenemia. The sensitivity to ovulation induction with CC were also improved. |
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Keywords: | polycystic ovarian syndrome clomiphene- resistance hyperandrogenimia Ganshao Capsule |
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