Isolation impairs place preference conditioning to morphine but not aversive learning in mice |
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Authors: | J-P Coudereau Marcel Debray Claire Monier Jean-Marie Bourre Henriette Frances |
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Affiliation: | (1) INSERM U 26, Hopital Fernand Widal, 200 rue de Faubourg St. Denis, F-75475 Paris Cedex 10, France, FR;(2) Laboratoire de Biostatistiques, Faculté de Pharmacie, 4 Avenue de l’observatoire, F-75006 Paris, France, FR |
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Abstract: | Morphine (8–100 mg/kg IP) induces place preference conditioning in mice. The effect of two different periods of isolation
(15 and 30 days) was examined. Mice isolated for 15 days but not 30 days exhibited place preference conditioning to morphine
(8 mg/kg). After 30 days of isolation morphine could not induce place preference conditioning with the following doses (8, 16, 64, 100 mg/kg).
Social regrouping of male mice previously isolated for 30 days with naive female mice for 15 or 30 days resulted in a reappearance
of the conditioned place preference to morphine (16 mg/kg). The specificity of this associative deficit was examined by testing
learning in isolated compared to non-isolated mice in two distinct settings: escape learning in the Morris water maze and
passive avoidance acquisition and retention. On the Morris water maze isolated mice did not differ from non-isolated mice
regarding place learning, the probe trial or extinction. Isolated mice were unimpaired in passive avoidance acquisition and
retention. It was concluded that the deficits in place preference conditioning were not the result of a global learning impairment
in isolated mice.
Received: 10 April 1996 /Final version: 20 September 1996 |
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Keywords: | Isolation Place preference conditioning Morphine Learning |
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