对放射性肠炎的认识及其可能的机制探讨

放射性肠炎严重影响盆腔肿瘤放疗患者的生活质量,作为一种放疗相关的肠道炎症,相关的基础研究显示放射性肠炎本质上是一种黏膜的炎症,由于程序性坏死可能介导了炎症性肠病的发生,因此,同样作为肠道炎症性疾病的一种,程序性坏死可能也介导了放射性肠炎的发生发展。本文拟对放射性肠炎的本质以及可能的发生机制进行综述,期待能够指导放射性肠炎的治疗,进而有望提高患者的生活质量。

Understanding of radiation enteritis and its possible pathogenic mechanism

Radiation enteritis significantly affects the quality of life in the patients receiving radiotherapy due to pelvic tumor.As an intestinal inflammation related to radiotherapy, radiation enteritis is an inflammation of the mucous membrane in nature based on some basic research.Studies demonstrate that programmed necroptosis might play a role in the development of inflammatory bowel disease;therefore, as a subtype of inflammatory bowel disease, programmed necroptosis also might play a role in the development and progression of radiation enteritis.This paper aims to review the studies about the nature and pathogenic mechanism in order to contribute to the treatment of radiation enteritis and improve patients' quality of life.