| 托吡酯和丙戊酸钠治疗特发性全面性强直阵挛发作的临床疗效比较 |
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| 引用本文： | 李玉玲,王秀红,万雨明.托吡酯和丙戊酸钠治疗特发性全面性强直阵挛发作的临床疗效比较[J].医学理论与实践,2002,15(8):899-900. |
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| 作者姓名： | 李玉玲 王秀红 万雨明 |
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| 作者单位： | 东风汽车公司茅箭医院内科,湖北,十堰,442000 |
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| 摘 要： | 目的:探讨中等剂量托吡酯(商品名:妥泰)200mg对特发性全面性强直阵挛(GTCS)发作的疗效。方法:64例GTCS患者分成三组,妥泰单药治疗21例,妥泰联合丙戊酸钠治疗22例,另外21例采用丙戊酸钠治疗作对照。结果:妥泰单药组及联用药组治疗GTCS有效例数明显高于单用丙戊酸钠组,差异显著(P<0.05);同时单用妥泰组与联用丙戊酸钠组疗效相近(P>0.05)。结论:妥泰治疗GTCS疗效优于丙戊酸钠,且妥泰单一用药与联用丙戊酸钠治疗疗效相近。
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| 关 键 词： | 癫痫 特发性全面性强直阵挛发作 托吡酯 丙戊酸钠 |
| 修稿时间： | 2002年3月5日 |
A Clinical Contrast of Curative Effect of Topiramate and Sodium Valproate in Treatment of General Tonic Clonic Seizure |
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| LI Yuling,WANG Xiuhong,WAN Yuming.A Clinical Contrast of Curative Effect of Topiramate and Sodium Valproate in Treatment of General Tonic Clonic Seizure[J].The Journal of Medical Theory and Practice,2002,15(8):899-900. |
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| Authors: | LI Yuling WANG Xiuhong WAN Yuming |
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| Affiliation: | LI Yuling,WANG Xiuhong,WAN Yuming. Department of internal medicine,Maojian Hospital,Dongfeng Motor Corporation,Shiyan,Hubei Province 442012 |
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| Abstract: | Objective:To study the curative effect of middle dose of topiramate (200mg) on general tonic clonic seizure. (GTCS) Methods: 64cases of GTCS were divided into three groups. Group A: 22 cases of GTCS were treated with topiramate. Group B: 22 cases of GTCS were treated with topiramate plus sodium valproate.The other 21 cases group C received treatemnt with sodium valproate. Results: The effective rate in group A and B was higher than that in group C (P < 0.05 ) , and group A was similar to group B in the curative effect. The curative effect of topiramate for GTCS is better than sodium valproate. The curative effect of topiramate for GTCS. is similar to topiramate plus sodium valproate |
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| Keywords: | Epilepsy General tonic clonic Topiramate Sodium valproate |
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