白芍总苷联合阿维A治疗中、重度银屑病32例临床观察

目的观察白芍总苷联合阿维A治疗中、重度银屑病的临床疗效和安全性。方法 62例中、重度银屑病患者随机分为2组,治疗组32例,予口服白芍总苷600mg3次/d,阿维A0.5mg/(kg.d)治疗,对照组30例仅予口服阿维A0.5mg/(kg.d)治疗,疗程8周。以银屑病皮损面积和严重程度(PASI)评分评价疗效并记录不良反应。结果治疗8周后,治疗组PASI评分(4.36±3.12)低于对照组(6.38±2.81),差异有统计学意义(P<0.05);治疗组有效率(90.62%)高于对照组(76.67%)。差异有统计学意义(P<0.05)。两组未见明显不良反应。结论白芍总苷联合阿维A治疗中、重度银屑病的患者疗效好,安全性高。

A Clinical Study of Total Glucosides of Paeon Combined with Acitretin in the Treatment of Moderate to Severe Psoriasis

Objective To evaluate the efficacy and safety of total glucosides of paeon combined with Acitretin for the treatment of moderate to severe psoriasis.Methods Sixty-two cases of moderate to severe psoriasis were divided into two groups and treated for 8 weeks.The treatment group was treated with Total Glucosides of Paeon 600mg(tid) combined with Acitretin 0.5mg/(kg·d) and the control group was treated with Acitretin 0.5mg/(kg·d).The adverse reaction and the efficacy of treatment was evaluated by Psoriasis Area and Severity Index(PASI) scores.Results The PASI scores in the treatment group(4.36±3.12) were significantly lower than that of control group(6.38±2.81)(P<0.05).The efficacy rates in the treatment group(90.62%) were significantly higher than that of control group(76.67%)(P<0.05).There was not adverse reaction occurred in both two groups.Conclusion Total Glucosides of Paeon Combined with Acitretin showed good efficacy and safety for Moderate to Severe Psoriasis patients.