Liquid chromatographic determination of the enantiomers of ibuprofen in plasma using a chiral AGP column |
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| Authors: | K J Pettersson A Olsson |
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| Affiliation: | Department of Bioanalysis, Astra Research Centre AB, S?dert?lje, Sweden. |
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| Abstract: | A reversed-phase high-performance liquid chromatographic method has been developed for the determination of the R- and S-enantiomers of ibuprofen. The enantiomers and the internal standard 4-pentylphenylacetic acid are extracted from plasma, separated and quantified on a Chiral-AGP column using ultraviolet detection. The simplicity, sensitivity and precision of the method makes it convenient for use in pharmacokinetic studies. |
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