维生素D受体基因多态性与银屑病的关系

目的 探讨维生素D受体(VDR)基因多态性与银屑病的关系。方法 采用聚合酶链反应和限制性片段长度多态性(PCR-RFLP),对112例无血缘关系的银屑病患者和108例无血缘关系的健康人员的VDR基因型进行分析。结果 AA、Bb基因型在健康人中出现的频率仅7.4%及14.8%,而在银屑病人中出现的频率为19.6%及32.1%.进一步分析VDR基因型与银屑病患者性别、发病年龄、家族史等的关系,未发现显着相关。在统计等位基因A、a和B、b时,发现它们在两组人群中出现的频率差异均无显着性。结论 维生素D受体(VDR)基因型分布在银屑病患者与健康人中是显着不同的,纯合子AA基因型或杂合子Bb基因型的出现可能增加患银屑病的易患性。

The Association between Vitamin D Receptor Polymorphism and Psoriasis

Objective To study the correlation between vitamin D receptor(VDR)polymorphism and psoriasis in the Chinese patients.Methods VDR genotypes were determined by PCR-RFLP in 112unrelated psoriatic patients as well as 108unr elated healthy controls.Results AA and Bb genotypes were found to be ex-pressed more frequently in psoriatic patients(19.6%and 32.1%)than those in normal controls(7.4%and14.8%),respectively.However,no signifi cant correlation was identified between VDR polymorphismand sex,age at onset,family history of psoriasis in psoriatic patients.In addition,there was no significant difference in the fre-quency of A,a alleles and B,b alleles between normal controls and psoriatic patients.Conclusions There is a significant difference in VDR genotypes between psoriatic patients and normal controls.The presence of hom ozygote AA or heterozygote Bb might contribute to the susceptibility of psoriasis.