缺氧诱导因子-1α在宫颈癌中的表达及意义

目的探讨缺氧诱导因子-1α（HIF-1α）在宫颈癌发生发展过程中蛋白表达情况。方法应用免疫组织化学S-P方法检测HIF-1α在正常宫颈组织（NCE）20例、宫颈上皮内瘤变组织（CIN）28例、宫颈癌（ICC）组织70例中的表达情况。结果在正常宫颈上皮、宫颈上皮内瘤变组织、宫颈癌（I—IIA期）组织中，HIF-1α蛋白的阳性表达率分别是0、32．14％、72．86％（P〈0．01）。结论HIF-1α的表达与宫颈癌的发生发展密切相关，促进宫颈癌的发生发展。

Expression and Significance of HIF-1α in Uterine Cervix Cancer

Objective To investigate the expression of HIF-1α during the carcinogenesis and development of cervical carcinoma. Methods Immunohistochemistry technique（SP method）was employed to detect expression of HIF-1α in tissues from 20 cases of normal cervical epithelium（NCE）,28 cases of cervical intraepithelial neoplasia（CIN）and 70 cases of invasive carcinoma of cervix （ICC）. Results The positive rates of HIF-1α protein expression in NCE, CIN and ICC tissues were 0,32.14%, 72.86%（P〈0.01）. Conclusion Expression of HIF-1α displays a positive correlation and is closely related with the carcinogenesis and development of cervical carcinoma. HIF-1α protein promotes the development of cervical carcinoma.