神经生长因子对脑外伤后人格改变的影响

目的探讨神经生长因子（NGF）对脑外伤后的人格改变的影响及治疗效果。方法选取2006年4月1日至2008年9月1日本院脑外伤住院患者（入院时GCS评分10～12）的39例,按入院顺序完全随机分为对照组（19例）和治疗组（20例）。对照组以维生素B1、B12和高压氧等常规治疗并,并给予生理盐水2ml作空白对照;治疗组在常规治疗基础上,以神经生长因子（NGF）剂量为6000U/日,每日肌注1次。两组均以28天为一个疗程,期间观察其意识状态和肝肾功能变化。一疗程后通过症状自评量表（SCL-90）、艾森克人格问卷（EPQ）等对人格改变因素进行临床研究。结果两组神经功能变化无明显差异;与对照组比较,治疗组心理、人格水平显著改善（P〈0.05）;症状自评量表（SCL-90）大部分因子得分高于对照组（P〈0.05）。结论神经生长因子（NGF）对脑外伤后出现心理和人格变化有一定治疗作用。

Clinical effect of nerve growth factor on personality disorders after cerebral trauma

Objective To explore the effect of nerve growth factor (NGF) on personality disorders after cerebral trauma. Methods 39 inpatients (Glasgow coma scale, GCS10～12) with cerebral injury were dividedinto two groups. The patients in control group (n=19) was given conventional therapy such as vitamineB1, vitamineB12 and high pressure oxygen; the patients in study group (n=11) was given NGF 6000U/d intramuscularly for 28 days. During the treatment, liver and kidney function were monitored continually and GCS were measured. Personality disorders of patients were assessed with SCL-90 and EPQ analysis. Results There was no difference in GCS between two groups. Compared with the control group, there was a significant improvement in psychology and personality in study group. Conclusions Nerve growth factor (NGF) is effective in the treatment of brain injury.