辛伐他汀与洛伐他汀的降血脂作用比较

目的 在两种病理模型上比较辛伐他汀与洛伐他汀的降血脂作用。方法 通过食用高脂饲料制备食饵性高血脂大鼠模型和通过腹腔注射Triton WR1339制备高胆固醇血症大鼠模型。结果 辛伐他汀12mg/kg,6mg/kg可显著降低食饵性高血脂大鼠血清总胆固醇（TC），甘油三酯（TG），低密度脂蛋白胆固醇（LDL－C），胆胆固醇和肝甘油三酯水平，升高其血清高密度脂蛋白胆固醇（HDL－C）;并可显著降低Triton WR1339所高胆固醇血症大鼠血清总胆固醇和肝胆固醇。洛伐他汀的这些作用明显弱于相同剂量的辛伐他汀，且洛伐他汀无明显升高食饵性高血脂大鼠血清高密度脂蛋白胆固醇的作用。结论 在本实验条件下，辛伐他汀的降血脂作用明显强于同剂量的洛伐他汀。

Comparative Antihyperlipidemic Effects of Simvastatin and Lovastatin

AIM The purpose is to compare antihyperlipidemic action of Simvastatin and Lovastatin. METHODS Two hyperlipidemic modegl were induced by fedding a high lipidic diet and intraperitoneal injection Triton WR 1339 in rats. RESULTS Simvastatin could significantly reduce serum cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol(LDL-C ) concentrations and TC/HDL-C ratio, and increase the high density lipoprotein-cholesterol (HDL-C ) concentration in rats fed a high hipidic diet. In this model, it also lowered liver TC and TG levels. In addition, we found that serum TC and liver TC in Triton induced hyperlipemia rats were reduced by Simvastatin. Antihyperlipidemic action of Lovastatin is lower than that of Simvastatin. CONCLUSION These antihyperlipidemic effects of Simvastatin are more potent than those of lovastatin (P< 0. 05,P<0. 01).