艾滋病合并隐球菌性脑膜炎17例临床分析

目的 分析17例艾滋病合并隐球菌性脑膜炎的临床资料,提高艾滋病合并隐球菌脑膜灸的诊断水平.方法 回顾性分析2000年1月-2008年12月我院收治的17例艾滋病合并隐球菌性脑膜炎患者的临床资料.结果 17例病例主要表现为发热、神经系统症状(头痛、呕吐、意识障碍、抽搐及脑膜刺激征)及不同程度的艾滋病相关表现.所有病例颅内压升高,脑脊液(CSF)异常,CSF墨汁染色找到隐球菌.结论 艾滋病合并隐球菌性脑膜炎时,CSF墨汁染色是一种简单实用的诊断方法 .早期诊断,积极抗真菌治疗,同时联合RARRT,可降低病死率、提高患者生活质量、延长患者生命.

Clinical analysis for 17 cases of AIDS patients coinfected with Cryptococcus neoformans meningitis

Objective To analyze the clinical data of 17 cases of acquired immuneo-deficiency syndrome coinfected with Cryptococcus neoformans meningitis, and increase the diagnostic techniques of the coinfection. Methods 17 cases of AIDS patients coinfected with C. neoformans meningitis from January 2000 to December 2008 were retrospec-tively reviewed. Results The main clinical presentations included fever, nerve system symptoms(headache, vomit, loss of consciousness, spasm and meningeal irritation), and different degree of AIDS-related presentation. All the patients in-creased intracranial pressure, abnormal cerebrospinal fluid CSF and C. neoformans found through india ink staining of CSF. Conclusions India ink staining of CSF is an easy and ideal way to diagnose AIDS coinfected with C. neoformags meningitis. Early diagnosis, active treatment of anti-fungus and combination with HARRT can decrease the mortality, improve the life quality and prolong survival in AIDS patients.