涎腺透明细胞癌10例临床病理分析

目的 分析涎腺透明细胞癌(CCC)的临床病理特征。方法 对上海第二医科大学附属第九人民医院口腔医学院口腔病理科在1985年1月至2004年5月期间诊断为涎腺肿瘤的病例进行回顾性分析，确诊了10例CCC，并进行临床病理分析及随访。结果 10例CCC部位：7例腭部、1例舌根、1例磨牙后区、1例口底，男、女性各5例，平均年龄为55岁。光镜下肿瘤主要由排列成小梁状、带状、巢状、团块状的透明细胞及少量嗜酸性细胞组成，细胞周围常有玻璃样变物包绕。免疫组化：10例肿瘤细胞EMA、CK8呈阳性表达，5例CK18呈阳性表达，2例CKHMW呈阳性表达，CK10／13、S-100、SMA、Calponin均呈阴性表达。8例随访患者术后均无复发或转移。结论 CCC是一种独立的、低度恶性的涎腺肿瘤，好发于小涎腺，肿瘤可能来源于闰管储备细胞。

Clear cell carcinoma of salivary gland:a clinicopathologic study of 10 cases

Objective To analyze the clinicopathologic features of clear cell carcinoma of salivary gland.Methods All cases of salivary gland tumors enrolled from January 1985 to May 2004 were reviewed,and ten cases of CCC were indentified and analyzed by clinicopathology and immunohistochemistry. Results Seven tumors were from palate, one was from base of tongue, one in retromolar region, and one in floor of mouth. The mean age of five men and five women was 55 years. Microscopically, the tumors were predominantly composed of trabeculae, cords, nests, solid sheets of clear cells and a few eosinophilic cells, and the two kinds of tumor cells were surrounded by hyalinized stroma. Immunohistochemically, EMA and CK8 were positive in all cases, CK18 in five cases, CKHMW in two cases. CK10/13, S 100, SMA and Calponin were negative in all cases. There was no evidence of recurrence of disease or metastasis in eight followed up patients.Conclusions CCC is a distinctive low grade malignant salivary gland neoplasm, arising mainly in the minor salivary glands, and it may originate from intercalated duct reserve cells.