视觉分析18F-Florbetaben在认知功能正常中国人群脑内的分布特征

目的 探讨视觉分析β淀粉样蛋白（Aβ）示踪剂氟18-氟比他班（¹⁸F-FBB）在认知功能正常中国人群脑内的分布特征及安全性评价。 方法 前瞻性纳入经确诊的认知功能正常受试者31例,其中男14例,女17例,平均（65.0±7.69）岁,均进行¹⁸F-FBB PET/CT脑部显像。从31例中随机选取6例作为对照男2例,女4例,平均（66.0±7.19）岁]于1周后再进行碳11-匹兹堡化合物（¹¹C-PIB）PET/CT脑部显像。视觉定性评估¹⁸F-FBB和¹¹C-PIB在脑内的分布特征,并观察所有受试者注射¹⁸F-FBB后的不良事件。 结果 ¹⁸F-FBB在脑内正常分布特征为白质明显非特异性摄取,其余脑区均未见放射性摄取。31例¹⁸F-FBB受试者中30例（96.8%）为PET阴性显像,1例（3.2%）PET阳性显像,示踪剂主要浓聚于眶上额叶及外侧颞叶;6例¹¹C-PIB对照受试者中5例（83%）为PET阴性显像,1例¹¹C-PIB及¹⁸F-FBB PET均为阳性显像;¹⁸F-FBB的白质放射性摄取明显高于¹¹C-PIB 。注射¹⁸F-FBB后受试者中未见明确与药物相关的严重不良反应。 结论 在认知功能正常中国人群中¹⁸F-FBB的分布特征与¹¹C-PIB相同;¹⁸F-FBB药物使用安全,可用于无创性评估脑内Aβ沉积。

Visual analysis of the distribution of 18F-Florbetaben in the brain of Chinese with normal cognitive function

Objective To investigate the distribution of amyloid-β imaging agent ¹⁸F-Florbetaben (¹⁸F-FBB) in the brain of Chinese with normal cognitive function, and to evaluate the safety of ¹⁸F-FBB. Methods Thirty-one subjects with normal cognitive (14 males, 17 females, with an average age of 65.0±7.69 years) were prospectively enrolled in this study. All subjects underwent PET/CT brain imaging after ¹⁸F-FBB injection. Randomly selected 6 subjects from the 31 subjects, including 2 males and 4 females, with an average age of 66.0±7.19 years, underwent ¹¹C-Pittsburgh compound (¹¹C-PIB) PET/CT brain imaging one week later. Visual qualitative assessment method was used to analyze the distribution characteristics of ¹⁸F-FBB and ¹¹C-PIB in the brain. Adverse events after injection of ¹⁸F-FBB were monitored. Results The distribution of the ¹⁸F-FBB was characterized by obvious non-specific uptake in the white matter, and no radioactive uptake was seen in the remaining brain areas. After ¹⁸F-FBB injection, 30 of 31 (96.8%) had PET negative imaging, and 1 (3.2%) had PET positive imaging. The ¹⁸F-FBB was mainly concentrated in the orbitofrontal cortex and lateral temporal lobe. Among the 6 cases injected ¹¹C-PIB, 5 cases (83%) had PET negative imaging, and 1 case showed positive in both ¹¹C-PIB and ¹⁸F-FBB PET imaging. The ¹⁸F-FBB uptake was significantly higher than ¹¹C-PIB uptake in white matter. No clear drug-related adverse reaction was observed after ¹⁸F-FBB injection. Conclusion The distribution characteristics of ¹⁸F-FBB in Chinese with normal cognitive function are same as those of ¹¹C-PIB. ¹⁸F-FBB is safe to use and can be used for noninvasive assessment of Aβ protein deposition in brain.