辅助生殖促排卵过程中使用褪黑素与治疗结局关系的Meta分析

目的:系统评价在控制性超促排卵(COH)过程中使用褪黑素对辅助生殖助孕的有效性.方法:检索PubMed、Embase、The Cochrane Library、中国知网、维普、万方数据库及中国生物医学数据库公开发表的全部文献,检索时间是自建库至2020年1月.纳入关于COH过程中使用褪黑素治疗与辅助生殖治疗结局的随机对...

Meta-Analysis of Melatonin Supplementation during Controlled Ovarian Hyperstimulation for Women Undergoing Assisted Reproductive Technology

Objective:To evaluate the effectiveness of melatonin supplementation during controlled ovarian hyperstimulation for women undergoing assisted reproductive technology.Methods:We searched PubMed,Embase,the Cochrane Library,the CNKI Database,VIP Database,Wanfang Database and the Chinese Biomedicine(CBM)Database for eligible studies published by the end of January 2020.Two independent evaluators screened the randomized controlled trials retrieved the effects of melatonin supplementation during controlled ovarian hyperstimulation in women undergoing assisted reproductive technology.The quality of the included studies was assessed,and the data were extracted for meta-analysis using RevMan 5.3.Results:A total of 6 RCTs involving 767 cycles were included.Among them,419 cycles were in the melatonin group and 348 cycles in the control group.The meta-analysis showed that the numbers of MⅡoocytes,high-quality embryos and the E2 levels on hCG day in the melatonin group was significantly higher than those in the control group(P<0.05).The melatonin supplementation during controlled ovarian hyperstimulation moderately elevated the clinical pregnancy rate,but the difference was not significant(WMD=1.34,P=0.08,95%CI:0.96-1.86).However,there were no significant differences in the number of oocytes retrieved and embryos transplanted,fertilization rate and abortion rate between the two groups(P>0.05).Conclusions:The currently available evidence suggests that melatonin supplementation during controlled ovarian hyperstimulation for women undergoing assisted reproductive technology can improve the numbers of MⅡoocytes and high-quality embryos,and clinical pregnancy rate.Larger sample size and multicenter RCTs are needed to verify the above conclusions.