| 磁性水凝胶作为药物载体的应用研究进展 |
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| 引用本文： | 韩晓东,张稳,于坤,贾庆明,陕绍云,苏红莹.磁性水凝胶作为药物载体的应用研究进展[J].材料导报,2017,31(15):30-35. |
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| 作者姓名： | 韩晓东 张稳 于坤 贾庆明 陕绍云 苏红莹 |
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| 作者单位： | 昆明理工大学化学工程学院,昆明,650500 |
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| 基金项目： | 国家自然科学基金(51503090);昆明理工大学自然科学基金(14118713) |
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| 摘 要： | 磁性水凝胶是一类同时具有磁性材料、高分子材料及水凝胶的性质特点的无机/有机复合材料。因具有优良的磁学性能及生物相容性,其作为新一代的药物载体可以实现磁响应、磁靶向及磁热疗等功能,在药物控制释放领域具有广阔的应用前景。对磁性水凝胶的制备方法及其在药物载体领域的研究情况进行了综述,详细介绍了磁性水凝胶作为药物载体的两种药物释放机理(ON/OFF模型及热敏释放原理),及其在磁靶向药物控释、磁热疗和磁共振成像方面的应用研究现状。
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| 关 键 词： | 磁性纳米颗粒 水凝胶 药物载体 磁靶向 磁热疗 |
Advances in Application of Magnetic Hydrogels as Drug Carriers |
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| HAN Xiaodong,ZHANG Wen,YU Kun,JIA Qingming,SHAN Shaoyun and SU Hongying.Advances in Application of Magnetic Hydrogels as Drug Carriers[J].Materials Review,2017,31(15):30-35. |
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| Authors: | HAN Xiaodong ZHANG Wen YU Kun JIA Qingming SHAN Shaoyun and SU Hongying |
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| Affiliation: | Faculty of Chemical Engineering, Kunming University of Science and Technology, Kunming 650500,Faculty of Chemical Engineering, Kunming University of Science and Technology, Kunming 650500,Faculty of Chemical Engineering, Kunming University of Science and Technology, Kunming 650500,Faculty of Chemical Engineering, Kunming University of Science and Technology, Kunming 650500,Faculty of Chemical Engineering, Kunming University of Science and Technology, Kunming 650500 and Faculty of Chemical Engineering, Kunming University of Science and Technology, Kunming 650500 |
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| Abstract: | Magnetic hydrogel combines the properties and advantages of magnetic material, polymer material and hydrogel into a single platform, which is widely used as biomaterials. Because of their excellent magnetic properties and biocompatibility, magnetic hydrogel can be used as multifunctional drug delivery systems (DDS) for magnetic sensitive drug release, targeting, hyperthermia and magnetic resonance imaging (MRI). In this paper, recent progresses of the preparation and applications of magnetic hydrogel as drug delivery systems are reviewed. And the drug release mechanism of magnetic hydrogel, including the ON/OFF release model and temperature-sensitive release behavior are described in detail. |
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| Keywords: | magnetic nanoparticles hydrogel drug carrier magnetic targeting magnetic hyperthermia |
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