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| 骆驼蓬碱和去氢骆驼蓬碱的质谱裂解途径研究 | |
| 引用本文： | 张洪亮 谭 鹏 邬瑞光 罗玲娟 韩 静 王春国 邓昕祺 刘永刚. 骆驼蓬碱和去氢骆驼蓬碱的质谱裂解途径研究[J]. 世界中医药, 2013, 8(1): 85-86 |
| 作者姓名： | 张洪亮 谭 鹏 邬瑞光 罗玲娟 韩 静 王春国 邓昕祺 刘永刚 |
| 作者单位： | 1. 北京中医药大学中药学院,北京,100102;新疆医科大学中医院,乌鲁木齐,830028 2. 北京中医药大学中药学院,北京,100102 3. 新疆医科大学中医院,乌鲁木齐,830028 |
| 摘 要： | 目的：研究去氢骆驼蓬碱和骆驼蓬碱的质谱裂解机制。方法：两者用HPLC进行分离后，在正离子模式下，得到去氢骆驼蓬碱和骆驼蓬碱的质谱图。结果：解析了去氢骆驼蓬碱和骆驼蓬碱多级质谱碎片，主要发生RDA裂解、-CH，和-OH等自由基丢失，吲哚环稳定。结论：本研究丰富了去氢骆驼蓬碱和骆驼蓬碱的质谱裂解机制，为B-咔啉类生物碱的成分研究提供依据。 |
| 关 键 词： | 骆驼蓬碱 ESI—MS MS 裂解途径 去氢骆驼蓬碱 |
| 收稿时间： | 2012-08-30 |
The ESI /MS Study on the Fragmentation Pathways of the Harmaline and Harmine |
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| Zhang Hongliang,Tan Peng,Wu Ruiguang,Luo Lingjuan,Han Jing,Wang Chunguo,Deng Xinqi,Liu Yonggang. The ESI /MS Study on the Fragmentation Pathways of the Harmaline and Harmine[J]. World Chinese Medicine, 2013, 8(1): 85-86 | |
| Authors: | Zhang Hongliang Tan Peng Wu Ruiguang Luo Lingjuan Han Jing Wang Chunguo Deng Xinqi Liu Yonggang |
| Affiliation: | 1 (1 Beijing University of Traditional Chinese Medicine,Beijing,Post code: 100102; 2 Xinjiang Medical University,Urumqi,Post code: 830011) |
| Abstract: | Objective ：To study the fragmentation pathways of harmaline and harmine by etectrospray ionization mass spectrometry （ ESI- MSn）. Methods：Harmaline and harmine were analyzed by ESI-MSn in positive ion mode. The first and multi-stage mass spectrum dia- grams were obtained. Results： To analyze mass spectrometry fragments of the harmaline and harmine, under the positive mode, RDA decomposition occurred mainly, and - CH3, -OH were lost. Conclusion： The results enriched the mass spectrum decomposition, and provided the basis for the chemical constituents research of B-carboline alkaloid. |
| Keywords: | Harmaline ESI-MS/MS Fragmentation pathways Harmine |
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