乳癖安胶囊对实验性乳腺增生大鼠的作用及其机制研究

目的观察乳癖安胶囊对乳腺增生的治疗作用,并探讨其作用机制。方法采用苯甲酸雌二醇和黄体酮制备大鼠乳腺增生症模型,对大鼠乳房、乳头的直径和高度进行测量,放射免疫法测血清雌二醇(E2)、孕酮(P)浓度;组织病理学方法测乳腺小叶数、腺泡数、腺泡腔平均直径,判定乳腺增生类型并计算乳腺增生率,锥板法测血液黏度观察乳癖安胶囊对乳腺增生的治疗作用。结果乳癖安胶囊能抑制乳腺增生大鼠乳房、乳头增高、增大;调节血清E2和P浓度,改善E2/P比值;降低乳腺增生的发生率,改善病理组织变化,抑制乳腺增生程度;降低全血及血浆黏度。结论乳癖安胶囊具有良好的抗实验性大鼠乳腺增生的作用。

Effects and mechanism of Rupian capsule on the hyperplasia of mammary gland in rats

Objective To observe the effect and mechanism of Rupian capsule on hyperplasia of mammary gland in rats.Methods The hyperplasia of mammary gland rat model was established by estradiol benzoate and progesterone(P).The diameter and height of breast and nipples were measured by vernier caliper.Levels of estradiol(E2) and P in serum were detected by radioimmunoassay.The number of lobules of mammary gland,acinus and the average diameter of acinar lumina were accounted by histopathology.The blood viscosity was detected by the cone and plate method.Results Rupian capsule inhibited the amplification of breast and nipple,as well as modulated E2 and P levels and E2/P ratio.Meantime,Rupian capsule also decreased the incidence of mastoplasia,histopathological changes,hyperplasia of mammary gland,and blood viscosity.Conclusion Rupian capsule shows therapeutic effects on hyperplasia of mammary gland in rats.