| 2,3,5-三甲基吡嗪生产新工艺的研究 |
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| 引用本文： | 李谦和,刘德文.2,3,5-三甲基吡嗪生产新工艺的研究[J].精细石油化工,1998(1):19-21. |
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| 作者姓名： | 李谦和 刘德文 |
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| 作者单位： | 湖南师范大学精细催化合成研究所!长沙410081(李谦和，尹笃林，伏再辉)，湖南省长沙坪塘天然香料厂!410208(刘德文，刘雪明) |
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| 摘 要： | 介绍以丁二酮和丙二胺为原料合成2，3，5－三甲基吡嗪的新方法。重点考察了缩合反应温度、溶剂用量和脱氢反应时间对目标产物产率的影响，确定了合成2，3，5－三甲基吡嗪的生产工艺条件：以无水乙醇为溶剂，丁二酮、丙二胺、溶剂乙醇和DH型脱氢剂的投料配比为1：0．67：3：10（重量比），于O～－5℃缩合反应1～2h，再在溶剂回流温度下脱氢反应2～3h，2，3，5－三甲基吡嗪的收率按投料丁二酮计达59％，产品纯度≥99．0％。
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| 关 键 词： | 2，3，5－三甲基吡嗪 合成 丁二酮 丙二胺 |
STUDY ON THE TECHNOLOGY OF PREPARING 2, 3, 5 - TRIMETHLYPYRAZINE |
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| Li Qianhe, Yin Dulin and Fu Zaihui.STUDY ON THE TECHNOLOGY OF PREPARING 2, 3, 5 - TRIMETHLYPYRAZINE[J].Speciality Petrochemicals,1998(1):19-21. |
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| Authors: | Li Qianhe Yin Dulin and Fu Zaihui |
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| Abstract: | A novel method for the synthesis of 2, 3, 5 - trimethylpyrazine was studied using biacetyl and propylene diamine as raw materials. The optimum conditions were established: anhydrous ethyl alco hol as the solvent, ratio of biacetyl, propylene diamine, DH - type dehydrogenated agent and solvent is 1: 0. 67: 3: 10(by weight), condensation at 0~ - 5℃ for 1~2 h, and dehydrogenation at reflux ing temperature of ethyl alcohol for 2 ~ 3 h, 2, 3, 5 - trimethylpyrazine can he obtained with 59% yields based on biacetyl, and the purity is 99. 0% or more. |
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| Keywords: | 2 3 5 - trimethylpyrazine biacetyl propylene diamine synthesis |
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