Fingerprint Analysis of Codonopsis Radix by HPLC Coupled with Chemometrics Analysis |
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| Authors: | CHEN Fang-fang QI Huan-yang and SHI Yan-ping |
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| Affiliation: | CHEN Fang-fang;QI Huan-yang;SHI Yan-ping;Key Laboratory of Chemistry of Northwestern Plant Resources of the CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences;Graduate University of Chinese Academy of Sciences; |
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| Abstract: | Objective To establish a validated high performance liquid chromatography (HPLC) for the fingerprint analysis of Codonopsis Radix and for the determination of lobetyolin. Methods HPLC coupled with diode array detection method was employed to establish the fingerprint profile and quantitative determination of lobetyolin in Codonopsis Radix. Principal component analysis method was employed to analyze the 52 Codonopsis Radix samples. Results The reference chromatogram was generated with 25 common peaks showing good separation from adjacent peaks. Conclusion Statistical analysis of the obtained data demonstrates that the developed HPLC fingerprint combined with chemometric is a reliable method for the similar evaluation and quality assessment of Codonopsis Radix, and other traditional Chinese herbs. |
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| Keywords: | chemometrics Codonopsis Radix fingerprinting analysis HPLC quality control |
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