基因表达谱聚类/分类技术研究及展望

随着人类及多种模式生物全基因组测序基本完成,人类基因组计划的研究进入后基因组时代.后基因组时代研究的焦点已经从测序转向功能研究。聚类/分类技术作为分析基因表达谱和识别基因功能的重要工具之一,近年来获得很大的发展。对目前基因表达谱聚类/分类技术及它们的发展,进行了综述性的研究,分析了它们的优缺点,结合我们的研究,提出了解决问题的思路和方法,为基因表达谱的进一步研究提供了新的途径。

Research on Gene Expression Data Based on Clustering/classification Technology

As the work of sequencing the genome of the human and many model organisms has been partially or fully finished,the "postgenomic era" has begun. Scientists are turning their focus toward identifying gene function from sequencing. Clustering technology, as one of the important tools of analyzing gene expression data and identifying gene function, has been used widely. In this paper we discuss main clustering technology about gene expression data at present, analyze their advantages and disadvantages, present the methods to solve the problems and give new approaches to study gene expression data.