普萘洛尔治疗婴幼儿血管瘤的研究进展

婴幼儿血管瘤是婴幼儿时期最常见的先天性良性血管内皮细胞增生性肿瘤。普萘洛尔为非选择性β受体阻断药，临床常用于治疗心律失常、心绞痛、高血压等，普萘洛尔对血管瘤治疗作用的意外发现，使国内外掀起了对这个经典老药研究的热潮。普萘洛尔对婴幼儿血管瘤的疗效在临床观察中得到了肯定，其安全性及安全剂量尚需要大规模样本对照研究做进一步评估。

Research Progress in the Treatment of Infantile Hemangiomas by Propranolol

Objective：Infantile hemangiomas is the most common tumor in infants with congenital benign endothelial cell prolifera-tion. Propranolol is a non-selectiveβ-blocker commonly used in the treatment of arrhythmia, angina and hypertension, etc. Propranolol used in the treatment of hemangiomas was an accidental discovery, which creates a trend of research on the classic old drug at home and abroad. The efficacy of propranolol in the treatment of infantile hemangiomas has been affirmed in the clinical observation;howev-er, the safety and safe dosage need to be further evaluated by large sample control studies.